Chen Yihan, Zhang Li, Liu Jinfeng, Zhang Pingyu, Chen Xiaoyuan, Xie Mingxing
1 Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 2 Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD.
Transplantation. 2017 Sep;101(9):1977-1986. doi: 10.1097/TP.0000000000001780.
Acute rejection (AR) remains the biggest challenge during the first year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the criterion standard for AR, endomyocardial biopsy has several limitations because of its inherent invasiveness and morbidity. Traditional imaging techniques, such as echocardiography and cardiac magnetic resonance imaging, are of certain value for AR, but their diagnostic criteria and accuracy remain in question. Molecular imaging sheds new light on AR diagnosis because it can provide information about gene expression and the location of molecules and cells. This article reviews the latest research and applications of several typical modalities of molecular imaging used in AR and discusses their advantages and disadvantages.
尽管免疫抑制疗法取得了进展，但急性排斥反应（AR）仍然是心脏移植后第一年面临的最大挑战。早期发现和控制AR对于移植受者的生存至关重要。然而，作为AR的标准检测方法，心内膜心肌活检由于其固有的侵入性和发病率而存在若干局限性。传统成像技术，如超声心动图和心脏磁共振成像，对AR具有一定价值，但其诊断标准和准确性仍存在疑问。分子成像为AR诊断带来了新的思路，因为它可以提供有关基因表达以及分子和细胞位置的信息。本文综述了用于AR的几种典型分子成像模式的最新研究和应用，并讨论了它们的优缺点。
