Young L T, Kish S J, Li P P, Warsh J J
Department of Psychiatry, University of Toronto, Clarke Institute of Psychiatry, Canada.
Neurosci Lett. 1988 Nov 22;94(1-2):198-202. doi: 10.1016/0304-3940(88)90295-9.
Inositol 1,4,5-trisphosphate (IP3) receptor binding sites were studied in autopsied brains from 10 subjects with dementia of the Alzheimer type (DAT) and 10 age-matched controls. In the parietal cortex and hippocampus, there was a 50-70% loss of [3H]IP3 binding whereas no significant changes were observed in frontal, occipital and temporal cortices, caudate or amygdala. Scatchard analysis confirmed a reduction in receptor density rather than a change in affinity. Since muscarinic receptors are robustly coupled to IP3 formation, our data demonstrate abnormalities beyond the muscarinic receptor recognition site in DAT.
