Department of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland.
Students' Scientific Club of Pathophysiologists, Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury, 10-082 Olsztyn, Poland.
Nutrients. 2023 Apr 23;15(9):2029. doi: 10.3390/nu15092029.
One of the most common cyclitols found in eukaryotic cells-Myo-inositol (MI) and its derivatives play a key role in many cellular processes such as ion channel physiology, signal transduction, phosphate storage, cell wall formation, membrane biogenesis and osmoregulation. The aim of this paper is to characterize the possibility of neurodegenerative disorders treatment using MI and the research of other therapeutic methods linked to MI's derivatives. Based on the reviewed literature the researchers focus on the most common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease and Spinocerebellar ataxias, but there are also works describing other seldom encountered diseases. The use of MI, d-pinitol and other methods altering MI's metabolism, although research on this topic has been conducted for years, still needs much closer examination. The dietary supplementation of MI shows a promising effect on the treatment of neurodegenerative disorders and can be of great help in alleviating the accompanying depressive symptoms.
在真核细胞中发现的最常见的环己醇之一——肌醇（MI）及其衍生物在许多细胞过程中发挥着关键作用，如离子通道生理学、信号转导、磷酸盐储存、细胞壁形成、膜生物发生和渗透压调节。本文的目的是描述使用 MI 治疗神经退行性疾病的可能性，并研究与 MI 衍生物相关的其他治疗方法。基于已审查的文献，研究人员专注于最常见的神经退行性疾病，如阿尔茨海默病、帕金森病、亨廷顿病和脊髓小脑共济失调，但也有描述其他罕见疾病的研究。尽管多年来一直在研究 MI、d-松醇和其他改变 MI 代谢的方法，但它们的使用仍需要更密切的研究。MI 的饮食补充显示出对治疗神经退行性疾病的有希望的效果，并可以极大地帮助缓解伴随的抑郁症状。
