阿尔茨海默病中的星形胶质细胞。
Astroglia in Alzheimer's Disease.
机构信息
Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK.
Faculty of Health and Medical Sciences, Center for Basic and Translational Neuroscience, University of Copenhagen, 2200, Copenhagen, Denmark.
出版信息
Adv Exp Med Biol. 2019;1175:273-324. doi: 10.1007/978-981-13-9913-8_11.
Abstract
Alzheimer's disease is the most common cause of dementia. Cellular changes in the brains of the patients suffering from Alzheimer's disease occur well in advance of the clinical symptoms. At the cellular level, the most dramatic is a demise of neurones. As astroglial cells carry out homeostatic functions of the brain, it is certain that these cells are at least in part a cause of Alzheimer's disease. Historically, Alois Alzheimer himself has recognised this at the dawn of the disease description. However, the role of astroglia in this disease has been understudied. In this chapter, we summarise the various aspects of glial contribution to this disease and outline the potential of using these cells in prevention (exercise and environmental enrichment) and intervention of this devastating disease.
摘要
阿尔茨海默病是痴呆症最常见的病因。患有阿尔茨海默病的患者大脑中的细胞变化在临床症状出现之前就已经发生了。在细胞水平上，最显著的是神经元的死亡。由于星形胶质细胞执行大脑的稳态功能，可以肯定的是，这些细胞至少在一定程度上是阿尔茨海默病的病因之一。从历史上看，Alois Alzheimer 本人在疾病描述的早期就已经认识到了这一点。然而，星形胶质细胞在这种疾病中的作用还没有得到充分的研究。在这一章中，我们总结了神经胶质细胞对这种疾病的各种贡献，并概述了利用这些细胞预防（运动和环境丰富）和干预这种破坏性疾病的潜力。
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