Moysés M R, Cabral A M, Vasquez E C
Departamento de Ciencias Fisiológicas, Universidade Federal do Esprito Santo, Vitória, ES, Brasil.
Pharmacol Res Commun. 1988 Nov;20(11):993-9. doi: 10.1016/s0031-6989(88)80127-9.
Alterations in vascular alpha-adrenoceptor responsiveness following sinoaortic denervation was studied in conscious rats. The arterial hypertension observed in baroreceptor denervated rats decreased progressively during the 30 days of observation. A pressor hyperresponsiveness to methoxamine (10-80 micrograms/kg, iv), was observed 3 to 7 days after baroreceptor denervation followed by a gradual normalization of the vascular reactivity. The results indicate a possible participation of an enhanced alpha 1-adrenoceptor-mediated vasoconstrictor component in the early phase of neurogenic hypertension.
在清醒大鼠中研究了去窦主动脉神经后血管α-肾上腺素能受体反应性的变化。在压力感受器去神经支配的大鼠中观察到的动脉高血压在观察的30天内逐渐降低。在压力感受器去神经支配后3至7天观察到对甲氧明（10 - 80微克/千克，静脉注射）的升压反应性增强，随后血管反应性逐渐恢复正常。结果表明，增强的α1-肾上腺素能受体介导的血管收缩成分可能参与了神经源性高血压的早期阶段。
