Vasquez E C, Bissoli N S, Moyses M R, Cabral A M
Departamento de Ciências Fisiológicas, UFES, Vitória, Brasil.
Braz J Med Biol Res. 1988;21(3):629-32.
The contractile reactivity to norepinephrine, methoxamine, and verapamil of the perfused mesenteric vascular bed from sinoaortic denervated (SAD) and sham-operated (SO) rats was studied 3 to 30 days after surgery. A gradual but incomplete reduction of arterial hypertension was observed in SAD rats throughout the study. The norepinephrine- and methoxamine-induced dose-response curves were similar in both SAD and SO groups on day 3, but shifted to the left on days 7 and 15 and demonstrated a tendency to shift to the right at 30 days. Verapamil-induced vasodilation was similar in both groups. Enhanced mesenteric vascular responsiveness to endogenous catecholamines could contribute to the increased vascular resistance.
研究了手术后3至30天，去窦弓神经（SAD）大鼠和假手术（SO）大鼠的灌注肠系膜血管床对去甲肾上腺素、甲氧明和维拉帕米的收缩反应性。在整个研究过程中，观察到SAD大鼠的动脉高血压逐渐但不完全降低。在第3天，SAD组和SO组中去甲肾上腺素和甲氧明诱导的剂量反应曲线相似，但在第7天和第15天向左移动，在第30天有向右移动的趋势。两组中维拉帕米诱导的血管舒张相似。肠系膜血管对内源性儿茶酚胺反应性增强可能导致血管阻力增加。
