钌催化 2-炔基苯胺的环异构化反应：通过 1,2-碳迁移合成 3-取代吲哚。
Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylanilides: Synthesis of 3-Substituted Indoles by 1,2-Carbon Migration.
机构信息
Department of Chemistry, Faculty of Science, Tokyo University of Science , Kagurazaka, Shinjuku, Tokyo 162-8601, Japan.
出版信息
J Am Chem Soc. 2017 Jun 14;139(23):7749-7752. doi: 10.1021/jacs.7b04564. Epub 2017 Jun 2.
PMID:28539042
Abstract
We developed ruthenium-catalyzed cycloisomerization of alkynylanilides that gave 3-substituted indoles in high yields. The reaction proceeded via the disubstituted vinylidene ruthenium complex that was formed by the 1,2-carbon migration.
摘要
我们开发了钌催化的炔基苯胺环化异构化反应，高产率地得到了 3-取代吲哚。反应通过 1,2-碳迁移形成的二取代乙烯基钌络合物进行。
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