Yanoff M
Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia.
Acta Ophthalmol Suppl (1985). 1988;184:59-61. doi: 10.1111/j.1755-3768.1988.tb02630.x.
Two studies, both retrospective, were done at our institution. The first study evaluated 100 consecutive patients with exfoliation (EX) syndrome found as an incidental finding in a private, general ophthalmology practice, to determine the incidence of glaucoma. The second determined the long-term course of EX as it relates to the onset of elevated intraocular pressure (IOP). In the first study, of 124 eyes having EX 78% had normal IOP, 15% had intraocular pressure greater than 22 mm Hg but no cupping or field loss (ocular hypertension or glaucoma suspect), and 7% had glaucoma. In the second study 347 patients who initially had normal IOPs and either unilateral or bilateral EX were followed over time. Elevated IOP developed in 35 patients (44 eyes) during the study. The cumulative probability for eyes with EX to develop elevated intraocular pressure was 5.3% in 5 years and increased to 15.4% in 10 years. These probabilities predict that patients with EX have a higher incidence of developing elevated intraocular pressure than would be expected in patients without EX of similar age.
我们机构进行了两项回顾性研究。第一项研究评估了在一家私立综合眼科诊所偶然发现的100例连续剥脱（EX）综合征患者，以确定青光眼的发病率。第二项研究确定了EX与眼内压（IOP）升高发作相关的长期病程。在第一项研究中，124只患有EX的眼睛中，78%的眼压正常，15%的眼压高于22 mmHg但无杯盘比改变或视野缺损（高眼压或青光眼可疑），7%患有青光眼。在第二项研究中，对347例最初眼压正常且有单侧或双侧EX的患者进行了长期随访。在研究期间，35例患者（44只眼）眼压升高。EX患者眼睛眼压升高的累积概率在5年内为5.3%，在10年内升至15.4%。这些概率表明，与年龄相仿但无EX的患者相比，EX患者眼压升高的发病率更高。
