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妊娠中期引产术后妊娠物残留期待疗法与刮宫术的疗效及并发症分析

[Expectant therapy versus curettage for retained products of conception after second trimester termination of pregnancy: analysis of outcomes and complications].

作者信息

Zeng Wen-Juan, An Sheng-Li, Huang Hao, Huang Qi-Tao, Li Fei-Feng, Wang Hai-Zhen, Cai Dan-Chun, Gao Yun-Fei

机构信息

Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail:

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2017 May 20;37(5):569-574. doi: 10.3969/j.issn.1673-4254.2017.05.01.

Abstract

OBJECTIVE

To evaluate the prognosis and complications of expectant therapy and curettage for retained product of conception (RPOC) after second trimester termination of pregnancy (TOP).

METHODS

A total of 270 patients with RPOC following second trimester TOP in Nanfang Hospital between January, 2014 and December, 2015 were included in this study. The duration of vaginal bleeding time and menstruation recovery interval were compared between patients receiving expectant therapy and curettage for RPOC, and binary logistic regression was used to assess the risk factors for complications in bivariate and multivariate analyses.

RESULTS

The duration of vaginal bleeding time was significantly longer in expectant therapy group than in curettage group (=0.005), while the menstruation recovery interval did not differ significantly between the two groups. The incidence of vaginal bleeding time for over 42 days was significantly higher in curettage group than in expectant therapy group (=0.040), and the incidence of a menstruation recovery interval beyond 60 days was comparable between them. The incidence of complications was significantly higher in curettage group than in expectant therapy group either with adjustment of age, gravidity, parity, history of uterine surgery status, gestational age, type of indications, regimens for TOP and induction-abortion interval (=18.26[95% : 3.57-93.42], < 0.001) or without adjustment (=10.60, [95% : 2.36-47.66], =0.002).

CONCLUSION

Expectant therapy and curettage for RPOC after second trimester TOP have comparable prognosis, but curettage is associated with a significantly higher rate of complications.

摘要

目的

评估孕中期终止妊娠(TOP)后妊娠物残留(RPOC)采用期待治疗和刮宫术的预后及并发症。

方法

纳入2014年1月至2015年12月在南方医院孕中期TOP后发生RPOC的270例患者。比较RPOC患者接受期待治疗和刮宫术的阴道出血时间及月经恢复间隔,并采用二元逻辑回归在双变量和多变量分析中评估并发症的危险因素。

结果

期待治疗组的阴道出血时间显著长于刮宫组(=0.005),而两组的月经恢复间隔无显著差异。刮宫组阴道出血时间超过42天的发生率显著高于期待治疗组(=0.040),且两组月经恢复间隔超过60天的发生率相当。无论是否调整年龄、孕次、产次、子宫手术史、孕周、指征类型、TOP方案及引产-流产间隔(=18.26[95%可信区间:3.57-93.42],<0.001)或不调整(=10.60,[95%可信区间:2.36-47.66],=0.002),刮宫组的并发症发生率均显著高于期待治疗组。

结论

孕中期TOP后RPOC采用期待治疗和刮宫术的预后相当,但刮宫术的并发症发生率显著更高。

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