内在和外部诱导电场电位对运动输出的脊髓控制。
Spinal control of motor outputs by intrinsic and externally induced electric field potentials.
作者信息
Jankowska Elzbieta
机构信息
Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
出版信息
J Neurophysiol. 2017 Aug 1;118(2):1221-1234. doi: 10.1152/jn.00169.2017. Epub 2017 May 24.
Abstract
Despite numerous studies on spinal neuronal systems, several issues regarding their role in motor behavior remain unresolved. One of these issues is how electric fields associated with the activity of spinal neurons influence the operation of spinal neuronal networks and how effects of these field potentials are combined with other means of modulating neuronal activity. Another closely related issue is how external electric field potentials affect spinal neurons and how they can be used for therapeutic purposes such as pain relief or recovery of motor functions by transspinal direct current stimulation. Nevertheless, progress in our understanding of the spinal effects of electric fields and their mechanisms has been made over the last years, and the aim of the present review is to summarize the recent findings in this field.
摘要
尽管对脊髓神经元系统进行了大量研究，但关于它们在运动行为中的作用仍有几个问题尚未解决。其中一个问题是，与脊髓神经元活动相关的电场如何影响脊髓神经网络的运作，以及这些场电位的效应如何与调节神经元活动的其他方式相结合。另一个密切相关的问题是，外部电场电位如何影响脊髓神经元，以及它们如何通过经脊髓直流电刺激用于治疗目的，如缓解疼痛或恢复运动功能。然而，在过去几年里，我们对电场的脊髓效应及其机制的理解取得了进展，本综述的目的是总结该领域的最新发现。
相似文献
1
Spinal control of motor outputs by intrinsic and externally induced electric field potentials.内在和外部诱导电场电位对运动输出的脊髓控制。
J Neurophysiol. 2017 Aug 1;118(2):1221-1234. doi: 10.1152/jn.00169.2017. Epub 2017 May 24.
2
Paired associative transspinal and transcortical stimulation produces plasticity in human cortical and spinal neuronal circuits.配对联想经脊髓和经皮质刺激可使人脑皮质和脊髓神经回路产生可塑性。
J Neurophysiol. 2016 Aug 1;116(2):904-16. doi: 10.1152/jn.00259.2016. Epub 2016 Jun 8.
3
Safety versus efficacy of spinal cord stimulation for the generation of motor-evoked potentials in the rat.脊髓刺激在大鼠中产生运动诱发电位的安全性与有效性
J Neurotrauma. 1991 Spring;8(1):27-44. doi: 10.1089/neu.1991.8.27.
4
[Synaptic effects on frog motor neurons during stimulation of the spinal cord dorsal roots and dorsal columns].[脊髓背根和背柱刺激期间对青蛙运动神经元的突触效应]
Biull Eksp Biol Med. 1971 May;71(5):6-10.
5
Spinal evoked potentials from the motor tracts.来自运动传导束的脊髓诱发电位。
J Neurosurg. 1983 Jan;58(1):38-44. doi: 10.3171/jns.1983.58.1.0038.
6
Syntheses of spinal cord field potentials in the terrapin.鳖脊髓场电位的合成
Biol Cybern. 1984;50(6):409-18. doi: 10.1007/BF00335198.
7
[Impulse activity of spinal cord motor neurons during prolonged ortho- and antidromic activation].[长时间正向和逆向激活期间脊髓运动神经元的冲动活动]
Fiziol Zh SSSR Im I M Sechenova. 1974 Sep;60(9):1369-75.
8
[Neuronal mechanisms of cortico-spinal motor systems].[皮质脊髓运动系统的神经元机制]
Fiziol Zh SSSR Im I M Sechenova. 1967 Nov;53(11):1311-21.
9
Modular organization of motor behavior.运动行为的模块化组织
Z Naturforsch C J Biosci. 1998 Jul-Aug;53(7-8):510-7. doi: 10.1515/znc-1998-7-806.
10
An Optogenetic Demonstration of Motor Modularity in the Mammalian Spinal Cord.哺乳动物脊髓中运动模块化的光遗传学证明
Sci Rep. 2016 Oct 13;6:35185. doi: 10.1038/srep35185.
引用本文的文献
1
Grid-based transcutaneous spinal cord stimulation: probing neuromodulatory effect in spinal flexion reflex circuits.基于网格的经皮脊髓刺激：探究脊髓屈曲反射回路中的神经调节作用。
J Neural Eng. 2025 Apr 7;22(2):026046. doi: 10.1088/1741-2552/adc6bd.
2
Transspinal Direct Current Electrical Stimulation Selectively Affects the Excitability of the Corticospinal System, Depending on the Intensity but Not Motor Skills.经脊髓直流电刺激根据强度而非运动技能选择性地影响皮质脊髓系统的兴奋性。
Life (Basel). 2023 Dec 16;13(12):2353. doi: 10.3390/life13122353.
3
Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives.揭示神经肌肉系统与年龄相关的损伤：从生物力学和神经生理学角度进行探索。
Front Physiol. 2023 Jun 22;14:1194889. doi: 10.3389/fphys.2023.1194889. eCollection 2023.
4
Boosting corticospinal system synaptic plasticity to recover motor functions.增强皮质脊髓系统的突触可塑性以恢复运动功能。
Neural Regen Res. 2023 Oct;18(10):2182-2183. doi: 10.4103/1673-5374.369103.
5
Trans-Spinal Direct Current Stimulation Targets Ca Channels to Induce Persistent Motor Unit Responses.经脊髓直流电刺激靶向钙通道以诱导持续性运动单位反应。
Front Neurosci. 2022 Apr 25;16:856948. doi: 10.3389/fnins.2022.856948. eCollection 2022.
6
The effect of cathodal transspinal direct current stimulation on tibialis anterior stretch reflex components in humans.经颅直流电刺激对人体胫骨前肌牵张反射成分的影响。
Exp Brain Res. 2022 Jan;240(1):159-171. doi: 10.1007/s00221-021-06243-0. Epub 2021 Oct 22.
7
Is there hope that transpinal direct current stimulation corrects motoneuron excitability and provides neuroprotection in amyotrophic lateral sclerosis?经脊柱直接直流电刺激是否有望纠正肌萎缩侧索硬化症运动神经元的兴奋性并提供神经保护？
Physiol Rep. 2021 Jan;9(2):e14706. doi: 10.14814/phy2.14706.
8
Transcutaneous spinal direct current stimulation increases corticospinal transmission and enhances voluntary motor output in humans.经皮脊髓直流电刺激可增加皮质脊髓传递并增强人类的自主运动输出。
Physiol Rep. 2020 Aug;8(16):e14531. doi: 10.14814/phy2.14531.
9
Spinal cord stimulation for the restoration of bladder function after spinal cord injury.脊髓刺激用于脊髓损伤后膀胱功能的恢复。
Healthc Technol Lett. 2020 Jun 25;7(3):87-92. doi: 10.1049/htl.2020.0026. eCollection 2020 Jun.
10
Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat.猫Ia传入纤维短暂高频刺激后脊髓中间神经元的放电情况
Front Integr Neurosci. 2020 Jan 24;13:75. doi: 10.3389/fnint.2019.00075. eCollection 2019.
本文引用的文献
1
Long-lasting increase in axonal excitability after epidurally applied DC.硬膜外应用直流电后轴突兴奋性的持久增加。
J Neurophysiol. 2017 Aug 1;118(2):1210-1220. doi: 10.1152/jn.00148.2017. Epub 2017 May 17.
2
Repeated anodal transcranial direct current stimulation induces neural plasticity-associated gene expression in the rat cortex and hippocampus.重复阳极经颅直流电刺激可诱导大鼠皮层和海马中与神经可塑性相关的基因表达。
Restor Neurol Neurosci. 2017;35(2):137-146. doi: 10.3233/RNN-160689.
3
Spinal cord direct current stimulation differentially modulates neuronal activity in the dorsal and ventral spinal cord.脊髓直流电刺激可差异性地调节脊髓背侧和腹侧的神经元活动。
J Neurophysiol. 2017 Mar 1;117(3):1143-1155. doi: 10.1152/jn.00584.2016. Epub 2016 Dec 28.
4
Does trans-spinal and local DC polarization affect presynaptic inhibition and post-activation depression?经脊髓和局部直流电极化是否会影响突触前抑制和激活后抑制？
J Physiol. 2017 Mar 1;595(5):1743-1761. doi: 10.1113/JP272902. Epub 2017 Jan 17.
5
Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS).经颅直流电刺激（tDCS）治疗应用的循证指南。
Clin Neurophysiol. 2017 Jan;128(1):56-92. doi: 10.1016/j.clinph.2016.10.087. Epub 2016 Oct 29.
6
Systematic evaluation of the impact of stimulation intensity on neuroplastic after-effects induced by transcranial direct current stimulation.经颅直流电刺激诱导的神经可塑性后效应中刺激强度影响的系统评价
J Physiol. 2017 Feb 15;595(4):1273-1288. doi: 10.1113/JP272738. Epub 2016 Nov 8.
7
Animal models of transcranial direct current stimulation: Methods and mechanisms.经颅直流电刺激的动物模型：方法与机制
Clin Neurophysiol. 2016 Nov;127(11):3425-3454. doi: 10.1016/j.clinph.2016.08.016. Epub 2016 Sep 10.
8
Intraspinal microstimulation produces over-ground walking in anesthetized cats.脊髓内微刺激可使麻醉猫进行地面行走。
J Neural Eng. 2016 Oct;13(5):056016. doi: 10.1088/1741-2560/13/5/056016. Epub 2016 Sep 13.
9
Supraspinal control of spinal reflex responses to body bending during different behaviours in lampreys.七鳃鳗在不同行为过程中对身体弯曲的脊髓反射反应的脊髓上控制
J Physiol. 2017 Feb 1;595(3):883-900. doi: 10.1113/JP272714. Epub 2016 Oct 13.
10
Electrical Identification and Selective Microstimulation of Neuronal Compartments Based on Features of Extracellular Action Potentials.基于细胞外动作电位特征的神经元隔室的电识别和选择性微刺激。
Sci Rep. 2016 Aug 11;6:31332. doi: 10.1038/srep31332.
Zotero 插件