Waites Ken B, Xiao Li, Liu Yang, Balish Mitchell F, Atkinson T Prescott
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Clin Microbiol Rev. 2017 Jul;30(3):747-809. doi: 10.1128/CMR.00114-16.
is an important cause of respiratory tract infections in children as well as adults that can range in severity from mild to life-threatening. Over the past several years there has been much new information published concerning infections caused by this organism. New molecular-based tests for detection are now commercially available in the United States, and advances in molecular typing systems have enhanced understanding of the epidemiology of infections. More strains have had their entire genome sequences published, providing additional insights into pathogenic mechanisms. Clinically significant acquired macrolide resistance has emerged worldwide and is now complicating treatment. susceptibility testing methods have been standardized, and several new drugs that may be effective against this organism are undergoing development. This review focuses on the many new developments that have occurred over the past several years that enhance our understanding of this microbe, which is among the smallest bacterial pathogens but one of great clinical importance.
是儿童和成人呼吸道感染的重要病因，其严重程度可从轻度到危及生命。在过去几年里，有许多关于这种微生物引起感染的新信息发表。美国现在有基于分子的新型检测方法可供商业使用，分子分型系统的进展增强了对感染流行病学的理解。更多菌株的全基因组序列已公布，为致病机制提供了更多见解。临床上显著的获得性大环内酯耐药性已在全球出现，现在使治疗变得复杂。药敏试验方法已经标准化，几种可能对这种微生物有效的新药正在研发中。本综述重点关注过去几年出现的许多新进展，这些进展增进了我们对这种微生物的理解，它是最小的细菌病原体之一，但具有重大临床意义。
