Waites Ken B, Crabb Donna M, Duffy Lynn B, Jensen Jorgen S, Liu Yang, Paukner Susanne
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.02008-16. Print 2017 Feb.
Lefamulin, an investigational pleuromutilin, was tested against a collection of 18 macrolide-susceptible and 42 macrolide-resistant Mycoplasma pneumoniae strains, and the results were compared with those of azithromycin, erythromycin, tetracycline, doxycycline, and moxifloxacin testing. Lefamulin was highly active against all strains tested, with all MICs at ≤0.008 μg/ml. The lefamulin MIC (0.002 μg/ml) for macrolide-resistant strains was the lowest among all drugs tested. Minimum bactericidal concentrations were within 2 dilutions of the MIC values, indicating a bactericidal effect.
莱法莫林是一种处于研究阶段的截短侧耳素类药物，对18株大环内酯类敏感和42株大环内酯类耐药的肺炎支原体菌株进行了测试，并将结果与阿奇霉素、红霉素、四环素、多西环素和莫西沙星的测试结果进行了比较。莱法莫林对所有测试菌株均具有高活性，所有最低抑菌浓度均≤0.008μg/ml。在所有测试药物中，莱法莫林对大环内酯类耐药菌株的最低抑菌浓度（0.002μg/ml）是最低的。最低杀菌浓度在最低抑菌浓度值的2个稀释度范围内，表明具有杀菌作用。
