Sovova Eliska, Sova Milan, Zapletalova Jana, Stejskal David, Sovova Marketa, Kaletova Marketa, Svobodova Gabriela, Kuca Irena, Janak Michal, Kaminek Milan
Department of Sports Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Jun;161(2):174-178. doi: 10.5507/bp.2017.018. Epub 2017 May 16.
Adipocyte fatty acid-binding protein (A-FABP) is a promising link between metabolic syndrome and atherosclerosis. Epicardial fat (EPI) is an independent risk factor for cardiovascular disease (CVD).
The aim of this pilot study was to evaluate the correlation between EPI and A-FABP in asymptomatic patients with a family history of CVD.
59 subjects (39 males) (median = 54 years old) were enrolled in the study and their EPI thickness and A-FABP levels were assessed.
EPI was found in 46 patients (77.9%). There were positive correlations between EPI and A-FABP (r=0.336; P=0.010), age (r=0.526; P<0.001), fibrinogen (r=0.304; P=0.023) and systolic blood pressure (r=0.279; P=0.034). A positive correlation was found between EPI and A-FABP in a subgroup of overweight and obese patients (0.389; P=0.041, 0.407; P=0.004) and in the subgroup of patients with excluded CVD (r=0.368; P=0.006).
We found a positive correlation between EPI and A-FABP in a group of patients with a family history of CVD and in subgroups of overweight and obese patients.
脂肪细胞脂肪酸结合蛋白（A-FABP）是代谢综合征与动脉粥样硬化之间一个有前景的关联因素。心外膜脂肪（EPI）是心血管疾病（CVD）的一个独立危险因素。
本初步研究的目的是评估有CVD家族史的无症状患者中EPI与A-FABP之间的相关性。
59名受试者（39名男性）（中位年龄 = 54岁）纳入本研究，并评估他们的EPI厚度和A-FABP水平。
46例患者（77.9%）发现有EPI。EPI与A-FABP（r = 0.336；P = 0.010）、年龄（r = 0.526；P < 0.001）、纤维蛋白原（r = 0.304；P = 0.023）和收缩压（r = 0.279；P = 0.034）之间存在正相关。在超重和肥胖患者亚组（r = 0.389；P = 0.041，r = 0.407；P = 0.004）以及排除CVD的患者亚组中（r = 0.368；P = 0.006），EPI与A-FABP之间存在正相关。
我们发现，在一组有CVD家族史的患者以及超重和肥胖患者亚组中，EPI与A-FABP之间存在正相关。
