有心血管疾病家族史患者的脂肪细胞脂肪酸结合蛋白与心外膜脂肪之间存在正相关。

Possitive correlation between adipocyte fatty acid-binding protein and epicardial fat in patients with a family history of cardiovascular disesase.

作者信息

Sovova Eliska, Sova Milan, Zapletalova Jana, Stejskal David, Sovova Marketa, Kaletova Marketa, Svobodova Gabriela, Kuca Irena, Janak Michal, Kaminek Milan

机构信息

Department of Sports Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.

Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.

出版信息

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Jun;161(2):174-178. doi: 10.5507/bp.2017.018. Epub 2017 May 16.

DOI:10.5507/bp.2017.018

PMID:28539672

Abstract

BACKGROUND

Adipocyte fatty acid-binding protein (A-FABP) is a promising link between metabolic syndrome and atherosclerosis. Epicardial fat (EPI) is an independent risk factor for cardiovascular disease (CVD).

OBJECTIVE

The aim of this pilot study was to evaluate the correlation between EPI and A-FABP in asymptomatic patients with a family history of CVD.

METHODS

59 subjects (39 males) (median = 54 years old) were enrolled in the study and their EPI thickness and A-FABP levels were assessed.

RESULTS

EPI was found in 46 patients (77.9%). There were positive correlations between EPI and A-FABP (r=0.336; P=0.010), age (r=0.526; P<0.001), fibrinogen (r=0.304; P=0.023) and systolic blood pressure (r=0.279; P=0.034). A positive correlation was found between EPI and A-FABP in a subgroup of overweight and obese patients (0.389; P=0.041, 0.407; P=0.004) and in the subgroup of patients with excluded CVD (r=0.368; P=0.006).

CONCLUSIONS

We found a positive correlation between EPI and A-FABP in a group of patients with a family history of CVD and in subgroups of overweight and obese patients.

摘要

背景

脂肪细胞脂肪酸结合蛋白（A-FABP）是代谢综合征与动脉粥样硬化之间一个有前景的关联因素。心外膜脂肪（EPI）是心血管疾病（CVD）的一个独立危险因素。

目的

本初步研究的目的是评估有CVD家族史的无症状患者中EPI与A-FABP之间的相关性。

方法

59名受试者（39名男性）（中位年龄 = 54岁）纳入本研究，并评估他们的EPI厚度和A-FABP水平。

结果

46例患者（77.9%）发现有EPI。EPI与A-FABP（r = 0.336；P = 0.010）、年龄（r = 0.526；P < 0.001）、纤维蛋白原（r = 0.304；P = 0.023）和收缩压（r = 0.279；P = 0.034）之间存在正相关。在超重和肥胖患者亚组（r = 0.389；P = 0.041，r = 0.407；P = 0.004）以及排除CVD的患者亚组中（r = 0.368；P = 0.006），EPI与A-FABP之间存在正相关。