Assar Shirin, Sadeghi Bahar, Davatchi Fereydoun, Ghodsi Seyyedeh Zahra, Nadji Abdolhadi, Shahram Farhad, Ashofte Farimah, Larimi Seyyedeh Roghieh, Sadeghi Masoud
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Iran.
Rheumatology Research Center, Tehran University of Medical Sciences, Iran.
Reumatologia. 2017;55(2):79-83. doi: 10.5114/reum.2017.67602. Epub 2017 Apr 28.
The pathergy skin test is a hypersensitivity reaction to a prick skin trauma caused by a pin or a needle, which is considered as a specific presentation in Behçet's disease (BD) and the precise mechanism of this test is not well elucidated. This study was designed to evaluate the association of pathergy reaction (PR) with the active clinical manifestations of BD patients, to assess the clinical importance of PR.
This was a cohort study on 1675 BD patients who fulfilled the entry criteria based on the International Criteria for Behçet's Disease (ICBD) from 1975 to 2011. The patients were divided into two groups; the pathergy positive group included 841 patients (50.2%) and the pathergy negative group 834 patients (49.8%). The active mucocutaneous and systemic disease manifestations were analyzed according to the presence of the PR. The odds ratio and 95% confidence interval (95% CI) were calculated for each item.
In this study, 841 patients (50.2%) had a positive pathergy test. Patient's mean age and mean disease duration were similar in the two groups (pathergy positive and pathergy negative patients). There was no association between positive pathergy test and age of patients, or disease duration. The PR was associated with male gender ( = 0.013), oral aphthosis ( < 0.001), pseudofolliculitis ( < 0.001), anterior uveitis ( = 0.001) and posterior uveitis ( = 0.028).
The presence of PR was associated with male gender, as well as some of mucocutaneous manifestations and uveitis in adult patients. There was no association with retinitis and vascular involvements. PR isn't associated with the severity of the disease.
针刺反应皮肤试验是对针或针头引起的皮肤穿刺创伤的一种超敏反应，被认为是白塞病（BD）的一种特异性表现，且该试验的确切机制尚未完全阐明。本研究旨在评估针刺反应（PR）与BD患者临床活动表现之间的关联，以评估PR的临床重要性。
这是一项队列研究，研究对象为1975年至2011年期间符合白塞病国际诊断标准（ICBD）纳入标准的1675例BD患者。患者被分为两组；针刺反应阳性组包括841例患者（50.2%），针刺反应阴性组包括834例患者（49.8%）。根据PR的存在情况分析黏膜皮肤和全身疾病的活动表现。计算每个项目的比值比和95%置信区间（95%CI）。
在本研究中，841例患者（50.2%）针刺试验呈阳性。两组患者（针刺反应阳性和针刺反应阴性患者）的平均年龄和平均病程相似。针刺试验阳性与患者年龄或病程之间无关联。PR与男性（P = 0.013）、口腔溃疡（P < 0.001）、假性毛囊炎（P < 0.001）、前葡萄膜炎（P = 0.001）和后葡萄膜炎（P = 0.028）相关。
PR的存在与成年男性患者以及某些黏膜皮肤表现和葡萄膜炎相关。与视网膜炎和血管受累无关。PR与疾病严重程度无关。
