促肾上腺皮质激素处理的绵羊中，心房利钠肽（1-28）的肾脏效应增强，但血流动力学效应未增强。

Enhancement of renal but not haemodynamic effects of atrial natriuretic peptide (1-28) in sheep treated with ACTH.

Parkes D G, Coghlan J P, McDougall J G, Scoggins B A

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1988 Dec;15(12):945-53. doi: 10.1111/j.1440-1681.1988.tb01040.x.

Abstract

The haemodynamic and renal effects of short-term infusion of human atrial natriuretic peptide (ANP) (1-28) were examined in sheep treated with ACTH and compared with the responses previously observed in normotensive sheep. 2. Infusion of ANP at 100 micrograms/h for 60 min in ACTH-treated sheep (5 micrograms/kg per day for 5 days) decreased blood pressure and produced a fall in both cardiac output and stroke volume. No changes were seen in heart rate and total peripheral resistance. 3. ANP produced large increases in urine volume, urinary sodium and chloride excretion, and further decreased plasma potassium concentration in the ACTH-treated sheep. Compared with normal sheep studied previously under the same conditions, the ACTH-treated sheep showed a much greater diuretic and natriuretic response to ANP, although the blood pressure response to ANP was similar in both states. 4. The change in renal responsiveness to ANP in sheep may be related to the increased blood volume of the ACTH-treated animals because volume expansion is known to enhance the renal effects of ANP.

摘要

研究了在接受促肾上腺皮质激素（ACTH）治疗的绵羊中短期输注人心房钠尿肽（ANP）（1 - 28）的血流动力学和肾脏效应，并与先前在正常血压绵羊中观察到的反应进行比较。2. 在接受ACTH治疗的绵羊（每天5微克/千克，共5天）中，以100微克/小时的速度输注ANP 60分钟，可降低血压，并使心输出量和每搏输出量下降。心率和总外周阻力未见变化。3. ANP使接受ACTH治疗的绵羊尿量、尿钠和氯排泄大幅增加，并使血浆钾浓度进一步降低。与先前在相同条件下研究的正常绵羊相比，接受ACTH治疗的绵羊对ANP的利尿和利钠反应要大得多，尽管两种状态下对ANP的血压反应相似。4. 绵羊对ANP的肾脏反应性变化可能与接受ACTH治疗的动物血容量增加有关，因为已知容量扩张会增强ANP的肾脏效应。