Parkes D G, Coghlan J P, McDougall J G, Scoggins B A
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia.
Clin Exp Hypertens A. 1987;9(12):2143-55. doi: 10.3109/10641968709159080.
The present study examines the effects of intravenous infusion of atrial natriuretic peptide (ANP) on blood pressure, heart rate, cardiac output, sodium excretion and urine output in conscious, chronically instrumented sheep. Human ANP (1-28) was infused into the jugular vein (I.V.) for 60 min at 20, 50, 100 and 500 micrograms/h. ANP caused a decrease in blood pressure at all doses which was associated with a reduction in stroke volume and cardiac output. There was also a decrease in right atrial pressure. At the two higher rates of infusion an increase in both heart rate and calculated total peripheral resistance was observed. These data are consistent with ANP acting on the venous side of the circulation to produce venodilatation, and a reduction in venous return, stroke volume and cardiac output. The increases in urinary sodium excretion and urine output observed when ANP was infused I.V. at 100 micrograms/h for 60 min were small. The data suggest that the minimum dose for effects on the cardiovascular system (20 micrograms/h) is less than that required to produce renal effects (100 micrograms/h). ANP has potent effects on the cardiovascular system in conscious sheep, exerting its effect on blood pressure primarily by its action on the venous circulation and on cardiac output.
本研究检测了静脉输注心房利钠肽（ANP）对清醒、长期植入仪器的绵羊的血压、心率、心输出量、钠排泄及尿量的影响。将人ANP（1 - 28）以20、50、100和500微克/小时的速率经颈静脉静脉内输注60分钟。ANP在所有剂量下均导致血压下降，这与每搏输出量和心输出量减少有关。右心房压力也降低。在两个较高的输注速率下，观察到心率和计算得出的总外周阻力均增加。这些数据与ANP作用于循环系统的静脉侧以产生静脉扩张、减少静脉回流、每搏输出量和心输出量一致。当以100微克/小时的速率静脉内输注ANP 60分钟时，观察到尿钠排泄和尿量的增加幅度较小。数据表明，对心血管系统产生影响的最小剂量（20微克/小时）低于产生肾脏效应所需的剂量（100微克/小时）。ANP对清醒绵羊的心血管系统有显著影响，主要通过作用于静脉循环和心输出量来影响血压。
