Ozkok Sercin, Ozkok Abdullah
Sercin Ozkok, Department of Radiology, Istanbul Medeniyet University, Goztepe Training and Research Hospital, 34760 Kadikoy, Istanbul, Turkey.
World J Nephrol. 2017 May 6;6(3):86-99. doi: 10.5527/wjn.v6.i3.86.
Contrast-induced acute kidney injury (CI-AKI) is one of the most common causes of AKI in clinical practice. CI-AKI has been found to be strongly associated with morbidity and mortality of the patients. Furthermore, CI-AKI may not be always reversible and it may be associated with the development of chronic kidney disease. Pathophysiology of CI-AKI is not exactly understood and there is no consensus on the preventive strategies. CI-AKI is an active research area thus clinicians should be updated periodically about this topic. In this review, we aimed to discuss the indications of contrast-enhanced imaging, types of contrast media and their impact on nephrotoxicity, major pathophysiological mechanisms, risk factors and preventive strategies of CI-AKI and alternative non-contrast-enhanced imaging methods.
对比剂诱导的急性肾损伤（CI-AKI）是临床实践中急性肾损伤（AKI）最常见的病因之一。CI-AKI已被发现与患者的发病率和死亡率密切相关。此外，CI-AKI可能并不总是可逆的，并且可能与慢性肾脏病的发生有关。CI-AKI的病理生理学尚未完全明确，关于预防策略也没有共识。CI-AKI是一个活跃的研究领域，因此临床医生应定期了解这一主题。在本综述中，我们旨在讨论对比增强成像的适应证、对比剂的类型及其对肾毒性的影响、主要病理生理机制、CI-AKI的危险因素和预防策略以及替代的非对比增强成像方法。
