Naqvi Rubina
Rubina Naqvi, Sindh Institute of Urology and Transplantation, Civil Hospital, Karachi 74200, Pakistan.
World J Nephrol. 2017 May 6;6(3):162-167. doi: 10.5527/wjn.v6.i3.162.
To report our experience of acute kidney injury (AKI) developed after exposure to poisonous substance.
Retrospective study where data was collected from case records of patients coming to this institute during January 1990 to May 2016. This institution is a tertiary care center for renal care in the metropolitan city of Karachi, Pakistan. History of ingested substance, symptoms on presentation, basic laboratory tests on arrival, mode of treatment and outcome were recorded from all patients and are presented here. Patients developing AKI after snake envenomation or scorpion stings are not included in this study.
During studied period 184 cases of AKI developing after poisoning were seen at our institution. The largest group was from paraphenyline diamine poisoning comprising 135 patients, followed by methanol in 8, organophosphorus compounds in 5, paraquat in 5, copper sulphate in 5, tartaric acid in 4, phenobarbitone in 3 and benzodiazipines, datura, rat killer, fish gall bladder, arsenic, boiler water, ammonium dichromate, acetic acid and herbs with lesser frequency. In 8 patients multiple substances were ingested in combination. Renal replacement therapy was required in 96% of patients. Complete recovery was seen in 72.28% patients, 20% died during acute phase of illness.
It is important to report poisonous substances causing vital organ failure to increase awareness among general population as well as health care providers.
报告我们关于接触有毒物质后发生急性肾损伤（AKI）的经验。
回顾性研究，收集了1990年1月至2016年5月期间来本机构就诊患者的病历数据。本机构是巴基斯坦卡拉奇大都市的一家三级肾脏护理中心。记录了所有患者摄入物质的历史、就诊时的症状、入院时的基本实验室检查、治疗方式及结果，并在此呈现。本研究不包括蛇咬伤或蝎子蜇伤后发生AKI的患者。
在研究期间，我们机构共收治了184例中毒后发生AKI的病例。最大的一组是对苯二胺中毒，共135例患者，其次是甲醇中毒8例、有机磷化合物中毒5例、百草枯中毒5例、硫酸铜中毒5例、酒石酸中毒4例、苯巴比妥中毒3例，以及苯二氮卓类、曼陀罗、杀鼠剂、鱼胆、砷、锅炉水、重铬酸铵、乙酸和草药中毒，频率较低。8例患者同时摄入了多种物质。96%的患者需要进行肾脏替代治疗。72.28%的患者完全康复，20%在疾病急性期死亡。
报告导致重要器官衰竭的有毒物质，对于提高普通人群以及医疗保健人员的认识很重要。
