Ebrahimi Elmira, Sabokbar Tayebeh, Eskandarieh Sharareh, Peyghambari Vahideh, Shirkoohi Reza
Group of Genetics, Cancer Research Center, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Neurology & Neurosciences Research Center, Qom University of Medical Sciences, Qom, Iran.
Iran J Public Health. 2017 Apr;46(4):537-544.
Exposure to endogenous hormones such as estrogen is known as a lifetime Breast Cancer (BC) risk factor. Polymorphisms in genes that are involved in the steroidogenic process, such as Cytochrome P450c17alpha (, affect individuals' susceptibility to BC. In Iran, the highest incident of BC is among young women. This study aimed to find prevalence of Single Nucleotide Polymorphisms (SNPs) in genes such as and significant correlation with age-oriented group of breast cancer.
In 2016, a case series study was conducted on a total population of 205 patients suffering from breast cancer referred to Cancer Institute, Imam Khomeini Hospital Complex, Tehran, Iran. This population consisted of 104 cases less than 40 yr old and 101 cases over 40. The genotype variants of were determined using PCR, followed by RFLP. The association of polymorphisms with the risk of BC in two different age groups was evaluated by calculating odds ratio and 95% confidence intervals using unconditional logistic regression.
Carriers of at least one A2 allele may have higher risk of developing breast cancer at younger age compared to patients with A1/A1 genotype (Odds Ratio: 1.99, 95% Confidence Interval: 1.11-3.57, 0.02).
gene polymorphisms may have influence on the early onset of breast cancer.
接触内源性激素如雌激素被认为是乳腺癌（BC）的终生风险因素。参与类固醇生成过程的基因多态性，如细胞色素P450c17α（），影响个体对乳腺癌的易感性。在伊朗，乳腺癌发病率最高的是年轻女性。本研究旨在发现基因如中的单核苷酸多态性（SNP）的患病率以及与不同年龄组乳腺癌的显著相关性。
2016年，对转诊至伊朗德黑兰伊玛目霍梅尼医院综合癌症研究所的205例乳腺癌患者进行了病例系列研究。该人群包括104例年龄小于40岁的病例和101例年龄大于40岁的病例。使用聚合酶链反应（PCR），随后进行限制性片段长度多态性分析（RFLP）来确定的基因型变体。通过使用无条件逻辑回归计算比值比和95%置信区间，评估两个不同年龄组中多态性与乳腺癌风险的关联。
与A1/A1基因型患者相比，至少携带一个A2等位基因的携带者在年轻时患乳腺癌的风险可能更高（比值比：1.99，95%置信区间：1.11 - 3.57，P = 0.02）。
基因多态性可能对乳腺癌的早期发病有影响。
