Department of Surgery, Cancer Institute, Cancer Research Center, Tehran University of Medical Sciences, Tehran.
Department of Gastroenterology, Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran.
Ann Oncol. 2011 Jan;22(1):93-97. doi: 10.1093/annonc/mdq303. Epub 2010 Jun 9.
breast cancer (BC) is the most common malignancy among Iranian women. Although the relative incidence of BC is low, the cause-specific mortality is much higher than developed countries. The present study surveyed the overall trend of BC in Tehran.
all breast pathologic records were studied in five major hospitals in Tehran during three phases (1: 1985-1995; 2: 1996-2000; and 3: 2001-2005). Malignant cases were classified according to the tumor-node-metastasis classification. Data were compared across the study.
Of 9050 medical records from male and female patients with 'breast disease', 2946 females with BC were included. A significant increase in the diagnosis of palpable early BCs (stage II increased, stage III decreased) was observed between phases 1 and 2. A relative increases in stages 0 and I were noted between phases 3 and 2. Nevertheless, 76.8% of cases were T2 or higher and 65.3% had positive lymph nodes in the last phase. The proportion of patients with stage IIIb was increased in phase 3, despite the reduction in phase 2.
despite the relative improvement in the status of BC patients, the vast majority are diagnosed in advanced stages. Specific screening measures should be implemented in Iran.
乳腺癌（BC）是伊朗女性中最常见的恶性肿瘤。尽管相对发病率较低，但特定原因的死亡率远高于发达国家。本研究调查了德黑兰的乳腺癌总体趋势。
在德黑兰的五所主要医院的三个阶段（1：1985-1995 年；2：1996-2000 年；3：2001-2005 年）研究了所有乳腺病理记录。恶性病例根据肿瘤-淋巴结-转移分类进行分类。对研究数据进行了比较。
在来自男性和女性“乳腺疾病”患者的 9050 份病历中，有 2946 名女性患有乳腺癌。在阶段 1 和 2 之间，可触及的早期乳腺癌（II 期增加，III 期减少）的诊断明显增加。在阶段 3 和 2 之间，0 期和 I 期的相对增加。然而，在最后一个阶段，76.8%的病例为 T2 或更高，65.3%的病例有阳性淋巴结。尽管在阶段 2 有所减少，但在阶段 3 中，IIIb 期患者的比例增加。
尽管 BC 患者的状况有所相对改善，但绝大多数患者仍处于晚期诊断。伊朗应实施特定的筛查措施。
