Strickland Sarah V, Kilgore Mark R, Simons Elise J, Rendi Mara H
Department of Pathology, University of Washington, Seattle, WA, United States.
Women's Cancer Care of Seattle, Section of Obstetrics and Gynecology, Northwest Hospital & Medical Center, University of Washington Medicine, Seattle, WA, United States.
Gynecol Oncol Rep. 2017 May 5;21:1-4. doi: 10.1016/j.gore.2017.05.001. eCollection 2017 Aug.
We describe the case of a 67 year old female with longstanding uterine leiomyomas who presented with fatigue, weight loss, elevated CA-125 and an enlarging mass arising from the posterior uterine fundus. Histologic sections of the mass contained a leiomyoma with interspersed foci of malignant epithelioid cells forming anastomosing vascular channels. The neoplastic cells were diffusely positive for CD31 and FLI1, supporting the morphologic impression of epithelioid angiosarcoma. Few cases of epithelioid angiosarcoma arising within a leiomyoma have been described. In this report we discuss this association and describe its relation with elevated CA-125.
我们报告了一例67岁患有长期子宫平滑肌瘤的女性病例，该患者出现疲劳、体重减轻、CA-125升高，且子宫底后部有一肿块不断增大。肿块的组织学切片显示为平滑肌瘤，其间散在恶性上皮样细胞灶，形成吻合的血管通道。肿瘤细胞CD31和FLI1弥漫性阳性，支持上皮样血管肉瘤的形态学诊断。文献中很少描述平滑肌瘤内发生上皮样血管肉瘤的病例。在本报告中，我们讨论了这种关联，并描述了其与CA-125升高的关系。
