Menczer Joseph, Schreiber Letizia, Berger Esther, Ben-Shem Erez, Golan Abraham, Levy Tally
Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel.
Isr Med Assoc J. 2014 Nov;16(11):697-9.
Background: Elevated serum levels of the epithelial marker CA125 are occasionally observed in leiomyosarcoma (LMS) patients.
To assess the immunohistochemical expression of this marker in the tissue of LMS.
The consecutive unselected records of all patients with LMS diagnosed during the period 1995-2012 were located and abstracted. After verification of the diagnosis, 4 μm unstained slides were prepared from each case for immunohistochemical staining for CA125. Sections of ovarian carcinoma known to express CA125 were used as positive controls.
We located 17 LMS patients from the period under study. Bleeding was the presenting symptom in 9 patients; the diagnosis was established prior to treatment in 11 patients. The tumor was in an advanced stage in 6 patients, and in 7 unstaged patients it was grossly confined to the uterus. Ten patients died within 14 months after the diagnosis. Serum CA125 levels prior to treatment were assessed in only 8 patients and were above normal limits (> 35 U/ml) in 3 of them. Two of the three with elevated serum levels were in stage III, and the third was an unstaged apparent stage I patient. None of the LMS tissue specimens demonstrated immunohistochemical expression of CA125.
CA125 was not immunohistochemically expressed in the tissue of any LMS tumors examined by us. The origin of elevated serum CA125 in some of these tumors is therefore not in its tissue and remains unknown.
背景：平滑肌肉瘤（LMS）患者偶尔会出现血清上皮标志物CA125水平升高的情况。
评估该标志物在LMS组织中的免疫组化表达。
查找并提取1995年至2012年期间确诊的所有LMS患者的连续未筛选记录。在确诊后，从每个病例中制备4μm未染色切片用于CA125免疫组化染色。已知表达CA125的卵巢癌切片用作阳性对照。
我们在研究期间找到了17例LMS患者。9例患者以出血为首发症状；11例患者在治疗前确诊。6例患者肿瘤处于晚期，7例未分期患者肿瘤大体局限于子宫。10例患者在确诊后14个月内死亡。仅8例患者在治疗前评估了血清CA125水平，其中3例高于正常范围（>35 U/ml）。血清水平升高的3例患者中，2例处于III期，第3例是未分期的明显I期患者。所有LMS组织标本均未显示CA125的免疫组化表达。
我们检查的任何LMS肿瘤组织中均未检测到CA125的免疫组化表达。因此，这些肿瘤中部分患者血清CA125升高并非源于肿瘤组织，其原因尚不清楚。
