抗真菌剂的研究。18. 5,5-二取代-3-苯基-3-(1H-咪唑-1-基甲基)-2-甲基异恶唑烷及相关化合物的体外活性
Studies on antifungal agents. 18. In vitro activity of 5,5-disubstituted-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methy lisoxazol idines and related compounds.
作者信息
Mullen G B, DeCory T R, Allen S D, Mitchell J T, St Georgiev V
机构信息
Department of Organic Chemistry, Pennwalt Corporation, Rochester, N.Y.
出版信息
Chemotherapy. 1988;34(6):444-7. doi: 10.1159/000238606.
PMID:2854041
Abstract
The in vitro antifungal activity of a series of novel 5,5-disubstituted-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methyli soxazolidines and related compounds against Trichophyton rubrum, Aspergillus fumigatus and Candida albicans was studied. The screening was performed in solid agar cultures and some structure-activity relationships involving the C-5-substitution pattern are discussed.
摘要
研究了一系列新型5,5-二取代-3-苯基-3-(1H-咪唑-1-基甲基)-2-甲基异恶唑烷及其相关化合物对红色毛癣菌、烟曲霉和白色念珠菌的体外抗真菌活性。在固体琼脂培养物中进行筛选，并讨论了一些涉及C-5取代模式的构效关系。
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