抗真菌剂的研究。20. 氮取代对新型3,5-二取代异恶唑烷体外活性的影响。
Studies on antifungal agents. 20. Effect of the nitrogen substitution on the in vitro activity of novel 3,5-substituted isoxazolidines.
作者信息
Swift P A, Mullen G B, Mitchell J T, Allen S D, St Georgiev V
机构信息
Department of Organic Chemistry, Pennwalt Corporation, Rochester, N.Y.
出版信息
Chemotherapy. 1989;35(2):130-2. doi: 10.1159/000238659.
PMID:2667902
Abstract
The effect of the nitrogen substitution on the in vitro antifungal activity of a series of novel cis-3,5-substituted isoxazolidine derivatives is investigated. The 2-(N-methyl) analogues 4-6 were found to be the most active compounds when tested in vitro against Trichophyton rubrum, Aspergillus fumigatus and Candida albicans, with MIC values ranging between 0.7 and 70 micrograms/ml.
摘要
研究了氮取代对一系列新型顺式-3,5-取代异恶唑烷衍生物体外抗真菌活性的影响。2-(N-甲基)类似物4-6在体外针对红色毛癣菌、烟曲霉和白色念珠菌进行测试时，被发现是活性最强的化合物，其最低抑菌浓度值在0.7至70微克/毫升之间。
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