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脉络膜骨瘤新出现的视力丧失

[Newly occurring loss of visual acuity in choroidal osteoma].

作者信息

Schuh A, Foerster P, Priglinger S, Eibl-Lindner K

机构信息

Augenklinik, LMU, Mathildenstr. 8, 80336, München, Deutschland.

Augenärzte Pasinger Hofgärten, München, Deutschland.

出版信息

Ophthalmologe. 2018 Mar;115(3):226-230. doi: 10.1007/s00347-017-0514-y.

DOI:10.1007/s00347-017-0514-y
PMID:28540579
Abstract

PURPOSE

Approach to loss of visual acuity in a patient with a choroidal osteoma (CO) which had been stable for seven years.

METHODS

Fluorescence angiography confirmed a choroidal neovascularization (CNV) as the cause of the loss of visual acuity. Treatment with intravitreal (IVT) injection of ranibizumab.

RESULTS

Increase of visual acuity and decrease of edema after IVT injection.

CONCLUSION

Monitoring is necessary even for primarily benign CO in order to detect secondary complications causing loss of visual acuity, e. g. secondary CNV. Anti-VEGF IVT represents an approved treatment option.

摘要

目的

探讨一名脉络膜骨瘤(CO)患者视力丧失的处理方法,该脉络膜骨瘤已稳定七年。

方法

荧光血管造影证实脉络膜新生血管(CNV)是视力丧失的原因。采用玻璃体内注射雷珠单抗进行治疗。

结果

玻璃体内注射后视力提高,水肿减轻。

结论

即使是原发性良性脉络膜骨瘤也需要进行监测,以便检测导致视力丧失的继发性并发症,例如继发性脉络膜新生血管。抗血管内皮生长因子玻璃体内注射是一种已获批准的治疗选择。

相似文献

1
[Newly occurring loss of visual acuity in choroidal osteoma].脉络膜骨瘤新出现的视力丧失
Ophthalmologe. 2018 Mar;115(3):226-230. doi: 10.1007/s00347-017-0514-y.
2
Rescue therapy with intravitreal aflibercept for choroidal neovascularization secondary to choroidal osteoma non-responder to intravitreal bevacizumab and ranibizumab.玻璃体内注射阿柏西普对脉络膜骨瘤继发脉络膜新生血管进行挽救治疗,此类患者对玻璃体内注射贝伐单抗和雷珠单抗无反应。
Int Ophthalmol. 2015 Jun;35(3):441-4. doi: 10.1007/s10792-015-0059-5. Epub 2015 Mar 12.
3
Dramatic response of choroidal neovascularization associated with choroidal osteoma to the intravitreal injection of bevacizumab (Avastin).脉络膜骨瘤相关脉络膜新生血管对玻璃体内注射贝伐单抗(阿瓦斯汀)的显著反应。
Graefes Arch Clin Exp Ophthalmol. 2007 Nov;245(11):1731-3. doi: 10.1007/s00417-007-0636-z. Epub 2007 Jul 25.
4
Retinal pigment epithelium tear formation following intravitreal ranibizumab injection in choroidal neovascularization secondary to choroidal osteoma.脉络膜骨瘤继发脉络膜新生血管接受玻璃体内注射雷珠单抗后视网膜色素上皮撕裂的形成
Cutan Ocul Toxicol. 2014 Sep;33(3):259-63. doi: 10.3109/15569527.2013.844702. Epub 2014 Feb 11.
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Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Choroidal Osteoma.光学相干断层扫描血管造影术用于检测脉络膜骨瘤继发的脉络膜新生血管形成。
Ophthalmic Surg Lasers Imaging Retina. 2016 Jan;47(1):69-72. doi: 10.3928/23258160-20151214-10.
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Intravitreal bevacizumab monotherapy for choroidal neovascularisation secondary to choroidal osteoma.玻璃体内注射贝伐单抗单药治疗脉络膜骨瘤继发的脉络膜新生血管。
Eye (Lond). 2016 Jun;30(6):843-9. doi: 10.1038/eye.2016.50. Epub 2016 Apr 1.
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Outcomes of anti-vascular endothelial growth factor therapy in the management of choroidal neovascularization associated with choroidal osteoma.抗血管内皮生长因子疗法治疗脉络膜骨瘤相关脉络膜新生血管的疗效
Retina. 2014 Sep;34(9):1750-6. doi: 10.1097/IAE.0000000000000187.
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Complications, treatments, and visual prognosis of choroidal osteomas.脉络膜骨瘤的并发症、治疗及视力预后
Graefes Arch Clin Exp Ophthalmol. 2022 May;260(5):1713-1721. doi: 10.1007/s00417-021-05487-4. Epub 2021 Nov 11.
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[Intravitreal injection of bevacizumab for CNV secondary to choroidal osteoma and follow-up by Spectral-Domain OCT].玻璃体内注射贝伐单抗治疗脉络膜骨瘤继发的脉络膜新生血管并采用光谱域光学相干断层扫描进行随访
J Fr Ophtalmol. 2012 Sep;35(7):508-13. doi: 10.1016/j.jfo.2011.11.009. Epub 2012 Jun 12.
10
Choroidal Osteoma with Choroidal Neovascular Membrane treated with Anti- vascular Endothelial Growth Factor: A Rare Case with Review of Literatures.脉络膜骨瘤合并脉络膜新生血管膜的抗血管内皮生长因子治疗:罕见病例并文献复习。
Nepal J Ophthalmol. 2021 Jul;13(24):196-201. doi: 10.3126/nepjoph.v13i2.33218.

本文引用的文献

1
Long-term outcomes of intravitreal injection of bevacizumab for choroidal neovascularization associated with choroidal osteoma.玻璃体内注射贝伐单抗治疗脉络膜骨瘤相关脉络膜新生血管的长期疗效。
Clin Ophthalmol. 2015 Mar 3;9:429-37. doi: 10.2147/OPTH.S78817. eCollection 2015.
2
Rescue therapy with intravitreal aflibercept for choroidal neovascularization secondary to choroidal osteoma non-responder to intravitreal bevacizumab and ranibizumab.玻璃体内注射阿柏西普对脉络膜骨瘤继发脉络膜新生血管进行挽救治疗,此类患者对玻璃体内注射贝伐单抗和雷珠单抗无反应。
Int Ophthalmol. 2015 Jun;35(3):441-4. doi: 10.1007/s10792-015-0059-5. Epub 2015 Mar 12.
3
Choroidal osteoma shows bone lamella and vascular channels on enhanced depth imaging optical coherence tomography in 15 eyes.
脉络膜骨瘤在15只眼中的增强深度成像光学相干断层扫描上显示出骨板和血管通道。
Retina. 2015 Apr;35(4):750-7. doi: 10.1097/IAE.0000000000000376.
4
Outcomes of anti-vascular endothelial growth factor therapy in the management of choroidal neovascularization associated with choroidal osteoma.抗血管内皮生长因子疗法治疗脉络膜骨瘤相关脉络膜新生血管的疗效
Retina. 2014 Sep;34(9):1750-6. doi: 10.1097/IAE.0000000000000187.
5
Optical coherence tomography of choroidal osteoma in 22 cases: evidence for photoreceptor atrophy over the decalcified portion of the tumor.22例脉络膜骨瘤的光学相干断层扫描:肿瘤脱钙部分光感受器萎缩的证据
Ophthalmology. 2007 Dec;114(12):e53-8. doi: 10.1016/j.ophtha.2007.07.037. Epub 2007 Sep 20.
6
Factors predictive of tumor growth, tumor decalcification, choroidal neovascularization, and visual outcome in 74 eyes with choroidal osteoma.74例脉络膜骨瘤患者中肿瘤生长、肿瘤脱钙、脉络膜新生血管形成及视力预后的预测因素
Arch Ophthalmol. 2005 Dec;123(12):1658-66. doi: 10.1001/archopht.123.12.1658.
7
Choroidal neovascular membrane associated with choroidal osteoma (CO) treated with trans-pupillary thermo therapy.经瞳孔温热疗法治疗的与脉络膜骨瘤相关的脉络膜新生血管膜
Indian J Ophthalmol. 2004 Dec;52(4):329-30.
8
Clinicopathologic reports, case reports, and small case series: surgical removal and histopathologic findings of a subfoveal neovascular membrane associated with choroidal osteoma.临床病理报告、病例报告及小病例系列:与脉络膜骨瘤相关的黄斑下新生血管膜的手术切除及组织病理学发现
Arch Ophthalmol. 2003 Feb;121(2):273-6. doi: 10.1001/archopht.121.2.273.
9
Photodynamic therapy for choroidal neovascularization associated with choroidal osteoma.光动力疗法治疗与脉络膜骨瘤相关的脉络膜新生血管
Retina. 2001;21(6):660-1. doi: 10.1097/00006982-200112000-00016.
10
Argon laser photoablation of a choroidal osteoma.脉络膜骨瘤的氩激光光凝术。
Retina. 1991;11(2):224-8. doi: 10.1097/00006982-199111020-00007.