内皮脂肪酶在脂质代谢、炎症和癌症中的作用。
The role of endothelial lipase in lipid metabolism, inflammation, and cancer.
作者信息
Yu Justine E, Han Shu-Yan, Wolfson Benjamin, Zhou Qun
机构信息
Department of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, USA.
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Chinese and Western Medicine, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.
出版信息
Histol Histopathol. 2018 Jan;33(1):1-10. doi: 10.14670/HH-11-905. Epub 2017 May 25.
Abstract
Endothelial lipase (LIPG) plays a critical role in lipoprotein metabolism, cytokine expression, and the lipid composition of cells. Thus far, the extensive investigations of LIPG have focused on its mechanisms and involvement in metabolic syndromes such as atherosclerosis. However, recent developments have found that LIPG plays a role in cancer. This review summarizes the field of LIPG study. We focus on the role of LIPG in lipid metabolism and the inflammatory response, and highlight the recent insights in its involvement in tumor progression. Finally, we discuss potential therapeutic strategies for targeting LIPG in cancer, and the therapeutic potential of LIPG as a drug target.
摘要
内皮脂肪酶（LIPG）在脂蛋白代谢、细胞因子表达和细胞脂质组成中起关键作用。到目前为止，对LIPG的广泛研究主要集中在其机制以及在动脉粥样硬化等代谢综合征中的作用。然而，最近的研究发现LIPG在癌症中也发挥作用。本综述总结了LIPG的研究领域。我们重点关注LIPG在脂质代谢和炎症反应中的作用，并强调其参与肿瘤进展的最新见解。最后，我们讨论了针对癌症中LIPG的潜在治疗策略，以及LIPG作为药物靶点的治疗潜力。
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