British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Edinburgh, United Kingdom .
Antioxid Redox Signal. 2018 Mar 20;28(9):819-836. doi: 10.1089/ars.2017.7174. Epub 2017 Jul 14.
Air pollution is a major global health concern with particulate matter (PM) being especially associated with increases in cardiovascular morbidity and mortality. Diesel exhaust emissions are a particularly rich source of the smallest sizes of PM ("fine" and "ultrafine") in urban environments, and it is these particles that are believed to be the most detrimental to cardiovascular health. Recent Advances: Controlled exposure studies to diesel exhaust in animals and man demonstrate alterations in blood pressure, heart rate, vascular tone, endothelial function, myocardial perfusion, thrombosis, atherogenesis, and plaque stability. Oxidative stress has emerged as a highly plausible pathobiological mechanism by which inhalation of diesel exhaust PM leads to multiple facets of cardiovascular dysfunction.
Diesel exhaust inhalation promotes oxidative stress in several biological compartments that can be directly associated with adverse cardiovascular effects.
Further studies with more sensitive and specific in vivo human markers of oxidative stress are required to determine if targeting oxidative stress pathways involved in the actions of diesel exhaust PM could be of therapeutic value. Antioxid. Redox Signal. 28, 819-836.
空气污染是一个主要的全球健康问题，颗粒物（PM）尤其与心血管发病率和死亡率的增加有关。柴油机尾气排放是城市环境中最小粒径 PM（“细”和“超细”）的特别丰富来源，而这些颗粒被认为对心血管健康最有害。最新进展：在动物和人类中对柴油机排气的受控暴露研究表明，血压、心率、血管张力、内皮功能、心肌灌注、血栓形成、动脉粥样硬化和斑块稳定性发生改变。氧化应激已成为一种高度合理的病理生物学机制，通过该机制，柴油机排气 PM 的吸入导致心血管功能障碍的多个方面。
柴油机排气吸入会在几个生物隔室中引起氧化应激，这与不良的心血管效应直接相关。
需要进行具有更敏感和特异的体内人类氧化应激标志物的进一步研究，以确定针对柴油机排气 PM 作用相关氧化应激途径是否具有治疗价值。抗氧化。氧化还原信号。28,819-836。
