[阿米宁对神经肌肉突触超微结构的影响]
[Effect of armin on the ultrastructure of the neuromuscular synapse].
作者信息
Golikov S N, Barantsevich R P, Kuznetsov V G, Sanotskiĭ V I
出版信息
Biull Eksp Biol Med. 1979 Jul;88(7):95-9.
Alterations induced by the cholinesterase inhibitor armin (5.10(-7) g/ml) in the ultrastructure of motor nerve endings of the rat phrenic diaphragmal preparations at rest or electric stimulation of the nerve were studied. It was shown that armin at rest induced ultrastructural lesions in the endings similar to those in the control preparations during nerve stimulation. Electric stimulation did not produce additional changes in the ultrastructure of the neuromuscular junction under armin action. It is suggested that the disorder of the nerve ending function may be of importance in the mechanism of the blocking action of armin on the neuromuscular transmission.
研究了胆碱酯酶抑制剂阿米因（5×10⁻⁷克/毫升）对处于静息状态或经神经电刺激的大鼠膈神经膈肌标本运动神经末梢超微结构的影响。结果表明，静息状态下的阿米因在神经末梢诱导出的超微结构损伤与对照标本在神经刺激时出现的损伤相似。在阿米因作用下，电刺激并未使神经肌肉接头的超微结构产生额外变化。提示神经末梢功能紊乱可能在阿米因对神经肌肉传递的阻断作用机制中具有重要意义。
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