通过限制性分析确定的新型禽肉瘤病毒PR2257的基因组结构。
Genome structure of a new avian sarcoma virus PR2257 determined by restriction analysis.
作者信息
Nehyba J, Svoboda J, Karakoz I, Rynditch A V, Geryk J
机构信息
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
出版信息
Folia Biol (Praha). 1988;34(5):289-300.
The genome structure of a new avian src-containing acute transforming virus, designated PR2257, was studied by restriction analysis. PR2257 was isolated from a sarcoma grown in a 155-day-old chick inoculated intraembryonally with a transformation-defective mutant of daPR-C retaining no src sequences. The 4.4-kb genome of PR2257 consists of the following regions: 5' LTR--spliced version of chicken c-src--incomplete env gene--3' LTR. This structure clearly indicates that PR2257 was generated by recombination between a td daPR-C and chicken c-src.
通过限制性分析研究了一种新的含禽源src的急性转化病毒PR2257的基因组结构。PR2257是从一只155日龄鸡体内生长的肉瘤中分离出来的，该鸡在胚胎内接种了不含src序列的daPR-C转化缺陷型突变体。PR2257的4.4kb基因组由以下区域组成：5'LTR-鸡c-src的剪接版本-不完整的env基因-3'LTR。这种结构清楚地表明PR2257是由td daPR-C和鸡c-src之间的重组产生的。
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