IL-12/23 在 T 细胞相关性慢性炎症中的作用：免疫缺陷和治疗性阻断的影响。
The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade.
机构信息
Division of Infection and Immunity, University College London, UK.
Department of Rheumatology, University College London Hospitals NHS Trust, London, UK.
出版信息
Rheumatology (Oxford). 2018 Feb 1;57(2):246-254. doi: 10.1093/rheumatology/kex186.
PMID:28541488
Abstract
In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal.
摘要
在这篇综述中，我们讨论了两种密切相关的细胞因子——IL-12 和 IL-23——在塑造免疫反应中的不同作用。鉴于目前利用生物制剂阻断这两条途径的治疗性发展，更好地了解这些细胞因子的免疫学功能至关重要。
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