Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Exp Dermatol. 2018 Jul;27(7):737-747. doi: 10.1111/exd.13676.
Immune cells and cytokines play an important role in the pathogenesis of psoriasis. Interleukin-12 (IL-12) and IL-23 promote cellular responses mediated by T cells, which contribute to an inflammatory loop responsible for the induction and maintenance of psoriatic plaques. Antibodies that inhibit IL-12/23 or IL-23 are key treatment options for patients with psoriasis. IL-12 and IL-23 also play a key role in immune responses to infections and tumors. A growing body of information from clinical trials, cohort studies, postmarketing reports, genetic studies and animal models provides insights into the potential biological relationships between IL-12/23 inhibition and malignancies. We summarize this information in tables and provide some context for the interpretation of these data with the goal of informing dermatologists who are using IL-12/23 or IL-23 inhibitors to treat patients with psoriasis.
免疫细胞和细胞因子在银屑病的发病机制中起着重要作用。白细胞介素-12（IL-12）和白细胞介素-23（IL-23）促进 T 细胞介导的细胞反应，有助于诱导和维持银屑病斑块的炎症循环。抑制 IL-12/23 或 IL-23 的抗体是治疗银屑病患者的关键治疗选择。IL-12 和 IL-23 也在感染和肿瘤的免疫反应中发挥关键作用。越来越多的临床试验、队列研究、上市后报告、遗传研究和动物模型的信息提供了关于 IL-12/23 抑制与恶性肿瘤之间潜在生物学关系的见解。我们将这些信息总结在表格中，并为解释这些数据提供一些背景，目的是为使用 IL-12/23 或 IL-23 抑制剂治疗银屑病患者的皮肤科医生提供信息。
