Flanagan Julianne C, Fischer Melanie S, Badour Christal L, Ornan Gili, Killeen Therese K, Back Sudie E
a Department of Psychiatry & Behavioral Sciences , Medical University of South Carolina , Charleston , South Carolina , USA.
b Department of Psychology , University of Kentucky , Lexington , Kentucky , USA.
J Dual Diagn. 2017 Jul-Sep;13(3):213-218. doi: 10.1080/15504263.2017.1312039. Epub 2017 May 25.
Identifying factors that influence treatment outcomes of emerging integrated interventions for co-occurring posttraumatic stress disorder (PTSD) and substance use disorder is crucial to maximize veterans' health. Dyadic adjustment suffers among individuals with PTSD and substance use disorder and may be an important mechanism of change in treatment. This exploratory study examined the association between dyadic adjustment and treatment outcomes in individual integrated treatment for co-occurring PTSD and substance use disorder.
Participants were treatment-seeking veterans (N = 15) participating in a larger randomized controlled trial examining the efficacy of a novel integrated treatment for co-occurring PTSD and substance use disorder. Multiple regression analyses controlling for baseline symptom severity and independent sample t-tests were used to examine the relation between dyadic adjustment and treatment outcome variables including PTSD, substance use disorder, and depression symptom severity.
Baseline dyadic adjustment was associated with session 12 PTSD symptom severity as measured by both the Clinician-Administered PTSD Scale (CAPS) and PTSD Checklist (PCL), such that participants with high dyadic adjustment had significantly lower session 12 CAPS and PCL scores compared to participants with low dyadic adjustment. Baseline dyadic adjustment was not associated with session 12 depression symptoms or frequency of substance use.
These findings suggest that while the primary determinant of treatment outcome in this sample is the application of an evidence-based intervention, dyadic adjustment may play a role in individual treatment outcome for some treatment-seeking veterans. Data from this study were derived from clinical trial NCT01365247.
确定影响创伤后应激障碍(PTSD)和物质使用障碍同时出现时新兴综合干预治疗效果的因素,对于最大化退伍军人的健康至关重要。患有PTSD和物质使用障碍的个体在二元适应方面存在问题,二元适应可能是治疗中重要的改变机制。本探索性研究考察了PTSD和物质使用障碍同时出现时,个体综合治疗中二元适应与治疗效果之间的关联。
参与者为寻求治疗的退伍军人(N = 15),他们参与了一项更大规模的随机对照试验,该试验旨在检验一种针对PTSD和物质使用障碍同时出现的新型综合治疗的疗效。使用控制基线症状严重程度的多元回归分析和独立样本t检验,来考察二元适应与包括PTSD、物质使用障碍和抑郁症状严重程度在内的治疗效果变量之间的关系。
基线二元适应与第12次治疗时通过临床医生管理的PTSD量表(CAPS)和PTSD检查表(PCL)测量的PTSD症状严重程度相关,即二元适应水平高的参与者与二元适应水平低的参与者相比,第12次治疗时的CAPS和PCL得分显著更低。基线二元适应与第12次治疗时的抑郁症状或物质使用频率无关。
这些发现表明,虽然该样本中治疗效果的主要决定因素是基于证据的干预措施的应用,但二元适应可能对一些寻求治疗的退伍军人的个体治疗效果起到作用。本研究数据源自临床试验NCT01365247。