Yang Yi-De, Song Jie-Yun, Wang Shuo, Liu Fang-Hong, Zhang Yi-Ning, Shang Xiao-Rui, Wang Hai-Jun, Ma Jun
Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China.
PLoS One. 2017 May 19;12(5):e0177973. doi: 10.1371/journal.pone.0177973. eCollection 2017.
Previous studies demonstrated a role of variations in sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) in obesity and blood lipids. But the associations between SCAP polymorphisms and blood pressure (BP) are not clear. This study aimed to investigate the relationship between genetic variations in SCAP and BP phenotypes in a Chinese pediatric population.
A case-control study on 702 high blood pressure (HBP) children and 1319 controls was conducted to explore the correlation between single nucleotide polymorphism markers (rs12487736 and rs12490383) of SCAP and BP phenotypes. The associations with continuous and categorical variables were examined by linear regression and logistic regression models under a dominant genetic model for the minor rs12487736 A allele and rs12490383 T allele.
The rs12487736 polymorphism was significantly associated with systolic BP (SBP) (β = 1.66, P = 0.003) and diastolic BP (DBP) (β = 1.35, P = 0.024) with age, age-squared, sex, study population and body mass index (BMI) adjusted under the dominant genetic model. The rs12490383 polymorphism was significantly associated with SBP (β = 1.71, P = 0.004) and SHBP (OR = 1.39, 95%CI: 1.04-1.86, P = 0.027). When analyzed by BMI categories, in the normal-weight children, no significant association between the SCAP polymorphisms and BP phenotypes was observed (all P > 0.05). However, in the overweight/obese children, rs12487736 was significantly associated with SBP (β = 1.6, P = 0.019) and SHBP (OR = 1.36, 95%CI: 1.02-1.82; P = 0.037), rs12490383 was associated with SBP (β = 2.04, P = 0.004) and SHBP (OR = 1.50, 95%CI: 1.10-2.05; P = 0.01).
This study demonstrated that SCAP rs12487736 and rs12490383 were significantly associated with SBP and SHBP in overweight/obese Chinese children. It provided the evidence for association of SCAP with SBP.
既往研究表明，固醇调节元件结合蛋白（SREBP）裂解激活蛋白（SCAP）的变异在肥胖和血脂中发挥作用。但SCAP基因多态性与血压（BP）之间的关联尚不清楚。本研究旨在探讨中国儿童人群中SCAP基因变异与BP表型之间的关系。
对702例高血压（HBP）儿童和1319例对照进行病例对照研究，以探讨SCAP的单核苷酸多态性标记（rs12487736和rs12490383）与BP表型之间的相关性。在次要rs12487736 A等位基因和rs12490383 T等位基因的显性遗传模型下，通过线性回归和逻辑回归模型检验与连续变量和分类变量的关联。
在显性遗传模型下，校正年龄、年龄平方、性别、研究人群和体重指数（BMI）后，rs12487736多态性与收缩压（SBP）（β = 1.66，P = 0.003）和舒张压（DBP）（β = 1.35，P = 0.024）显著相关。rs12490383多态性与SBP（β = 1.71，P = 0.004）和收缩期高血压（SHBP）（OR = 1.39，95%CI：1.04 - 1.86，P = 0.027）显著相关。按BMI类别分析时，在体重正常的儿童中，未观察到SCAP多态性与BP表型之间存在显著关联（所有P > 0.05）。然而，在超重/肥胖儿童中，rs12487736与SBP（β = 1.6，P = 0.019）和SHBP（OR = 1.36，95%CI：1.02 - 1.82；P = 0.037）显著相关，rs12490383与SBP（β = 2.04，P = 0.004）和SHBP（OR = 1.50，95%CI：1.10 - 2.05；P = 0.01）相关。
本研究表明，SCAP rs12487736和rs12490383与超重/肥胖中国儿童的SBP和SHBP显著相关。它为SCAP与SBP的关联提供了证据。
