Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, 100191, Beijing, China.
Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, 410081, Changsha, China.
Pediatr Res. 2019 Sep;86(3):389-395. doi: 10.1038/s41390-019-0402-z. Epub 2019 Apr 19.
Previous studies had revealed that sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) rs12487736 polymorphism was associated with blood pressure (BP), but whether rs12487736 could interact with lifestyle behaviors on BP is unknown.
A case-control study with 1092 Chinese children was conducted.
We found an interaction between rs12487736 and high calorie foods intake (fried chips/cakes/cookies) on systolic blood pressure (SBP) (P = 0.027), and rs12487736 was associated with SBP in the subgroup having high calorie foods at least once in the last week (b = 2.19, P = 0.025), but not in the subgroup not having high calorie foods. Also, interaction between protein intake (meat/fish/soy beans/egg) and rs12487736 on diastolic BP (DBP) was identified (P = 0.049); rs12487736 was associated with DBP in the subgroup consuming protein (meat/fish/soy beans/egg) <twice/day (b = 3.38, P = 0.014), but not in the subgroup ≥twice/day. There is combined effect between rs12487736 and physical activity on DBP. In the subgroup who were inactive (physical activity <1 h/day), rs12487736 was significantly associated with DBP (b = 3.27, P = 0.046), but not in the active group (physical activity ≥1 h/day). Similar combined effect between rs12487736 and soft drink was found.
Interactions or combined effects between SCAP and lifestyle behaviors on BP support the importance of promoting a healthy lifestyle in the children genetically predisposed to higher BP.
先前的研究表明，固醇调节元件结合蛋白（SREBP）切割激活蛋白（SCAP）rs12487736 多态性与血压（BP）有关，但 rs12487736 是否与生活方式行为相互作用影响 BP 尚不清楚。
采用病例对照研究，纳入了 1092 名中国儿童。
我们发现 rs12487736 与高卡路里食物摄入（炸薯条/蛋糕/饼干）之间存在交互作用，影响收缩压（SBP）（P=0.027），且 rs12487736 与过去一周至少食用一次高卡路里食物的亚组的 SBP 相关（b=2.19，P=0.025），但与未食用高卡路里食物的亚组无关。此外，还发现了蛋白质摄入（肉/鱼/大豆/蛋）与 rs12487736 对舒张压（DBP）之间的交互作用（P=0.049）；rs12487736 与每天摄入蛋白质（肉/鱼/大豆/蛋）<2 次的亚组的 DBP 相关（b=3.38，P=0.014），但与每天摄入蛋白质≥2 次的亚组无关。rs12487736 与体力活动对 DBP 存在联合作用。在不活跃（体力活动<1 小时/天）的亚组中，rs12487736 与 DBP 显著相关（b=3.27，P=0.046），但在活跃组（体力活动≥1 小时/天）中则无此相关性。还发现了 rs12487736 与软饮料之间存在类似的联合作用。
SCAP 与生活方式行为对 BP 的交互作用或联合作用支持在遗传上易患高血压的儿童中促进健康生活方式的重要性。
