Wutzler P, Wutke K, Bärwolff D, Reefschläger J
Institut für Medizinische Mikrobiologie, der Medizinischen Akademie Erfurt, DDR.
Z Gesamte Inn Med. 1988 Dec 1;43(23):677-80.
BVDU [(E)-5-(2-bromovinyl)-2'-deoxyuridine] has proved effective in the treatment of varicella-zoster virus diseases in patients with malignancies. In 13 out of 20 patients a prompt cessation of new vesicle formation accompanied by rapid resolution of fever, crusting and complete epithelialisation of cutaneous lesions were noted. Only in few cases a prolonged recovery from the severe zoster occurred. When starting the treatment later than 48 hours after the onset of initial rash the dissemination of epithelial lesions could not be prevented. BVDU was well tolerated. Laboratory abnormalities were observed only in some cases and did not result in interruption of treatment.
BVDU[（E）-5-（2-溴乙烯基）-2'-脱氧尿苷]已被证明对治疗恶性肿瘤患者的水痘-带状疱疹病毒疾病有效。20名患者中有13名患者新水疱形成迅速停止，同时发热迅速消退、结痂，皮肤损伤完全上皮化。只有少数严重带状疱疹患者恢复时间延长。当初发皮疹出现后48小时后才开始治疗时，上皮病变的扩散无法得到预防。BVDU耐受性良好。仅在某些病例中观察到实验室异常，且未导致治疗中断。
