Li J, Chen P, Li J, Gao X, Chen X, Chen J
Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
J Clin Pharm Ther. 2017 Oct;42(5):649-652. doi: 10.1111/jcpt.12559. Epub 2017 May 23.
Veillonella parvula is usually regarded as a contaminant bacteria associated with polymicrobial infection. Here we report a rare case of sepsis caused by V. parvula, which was successfully treated by chloramphenicol. In addition, the therapeutic strategy for V. parvula infection was reviewed.
A 55-year-old woman underwent surgery for lumbar spinal stenosis and developed high fever (39.5°C) after surgery, accompanied by chills and fatigue. V. parvula was isolated in blood culture and shown to be probably sensitive to both meropenem and chloramphenicol. No improvement was seen after 3 days of treatment with meropenem, and then, iv chloramphenicol (1.5 g once daily) was added to the regimen. The symptoms and fever resolved in 2 days. She was continuously treated with chloramphenicol for another 10 days before discharge.
The reported antibiotics in the therapy of infections caused by veillonella species include penicillins, metronidazole, cephalosporins, aminoglycosides, imipenem, clindamycin, doxycycline, erythromycin and chloramphenicol. To our knowledge, this is the first case describing successful treatment of V. parvula-caused sepsis with chloramphenicol.
小韦荣球菌通常被视为与多种微生物感染相关的污染菌。在此，我们报告一例罕见的由小韦荣球菌引起的败血症病例，该病例通过氯霉素成功治愈。此外，还对小韦荣球菌感染的治疗策略进行了综述。
一名55岁女性接受了腰椎管狭窄手术，术后出现高热（39.5°C），伴有寒战和乏力。血培养分离出小韦荣球菌，结果显示其可能对美罗培南和氯霉素均敏感。使用美罗培南治疗3天后病情未见改善，随后在治疗方案中加用静脉注射氯霉素（每日1次，每次1.5 g）。症状和发热在2天内消退。出院前，她继续接受了10天的氯霉素治疗。
已报道的用于治疗韦荣球菌属感染的抗生素包括青霉素、甲硝唑、头孢菌素、氨基糖苷类、亚胺培南、克林霉素、强力霉素、红霉素和氯霉素。据我们所知，这是第一例描述用氯霉素成功治疗小韦荣球菌引起的败血症的病例。
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