Karki Sailesh, Mainali Arjun, Pandey Sagar, Uprety Navodita, Panigrahi Kalpana, Adhikari Samaj
Internal Medicine, One Brooklyn Health-Interfaith Medical Center, Brooklyn, USA.
Cureus. 2023 Jun 29;15(6):e41152. doi: 10.7759/cureus.41152. eCollection 2023 Jun.
Colorectal carcinoma has increasingly been reported to be associated with gut microbial dysbiosis. , , , , etc., are gut microbes commonly associated with colorectal carcinoma. Gut microbial dysregulation secondary to infectious, inflammatory, toxin exposure or change in dietary habits coupled with the disruption of the inner mucosal layer overlying the luminal epithelium is hypothesized as the inciting events leading to microbial invasion and subsequent tumorigenesis. Although the precise mechanism is unclear, disruption of normal host responses like inflammation, apoptosis, cellular proliferation, free radical injury, production of oncogenic toxins, etc., is postulated to play a role. We report a case of in a patient with metastatic colorectal carcinoma without a preceding history of periodontal disease. The patient was managed with ampicillin-sulbactam, which was followed by subsequent negative blood cultures. This case report signifies the association of gut microbiota like with colorectal carcinoma and the importance of subsequent screening for colorectal cancer following .
越来越多的报道称，结直肠癌与肠道微生物失调有关。[具体微生物名称1]、[具体微生物名称2]、[具体微生物名称3]、[具体微生物名称4]等是通常与结直肠癌相关的肠道微生物。继发于感染、炎症、毒素暴露或饮食习惯改变的肠道微生物失调，再加上覆盖管腔上皮的内粘膜层的破坏，被认为是导致微生物入侵和随后肿瘤发生的诱发事件。虽然确切机制尚不清楚，但推测正常宿主反应如炎症、细胞凋亡、细胞增殖、自由基损伤、致癌毒素产生等的破坏起到了一定作用。我们报告了一例转移性结直肠癌患者发生[具体感染情况]的病例，该患者既往无牙周病病史。患者接受氨苄西林-舒巴坦治疗，随后血培养转阴。本病例报告表明[具体微生物名称]等肠道微生物群与结直肠癌的关联，以及[具体微生物感染后]后续筛查结直肠癌的重要性。
