Falase E A, Otolorin E O, Ladipo O A
Department of Obstetrics & Gynaecology, University College Hospital, Ibadan, Nigeria.
Afr J Med Med Sci. 1988 Dec;17(4):209-13.
Eight hundred and ten patients who accepted to use depo-medroxyprogesterone acetate (DMPA) for contraception were studied over a period of 11 years (1976-1986). Important side-effects observed were amenorrhoea (36.3%), weight gain (15.8%), weight loss (10.6%), metrorrhagia (6.7%) and menorrhagia (6.0%). Amenorrhoea, menorrhagia and metrorrhagia were major reasons for discontinuation of DMPA in 11% of acceptors. There were no cases of pregnancy, genital or breast malignancies during DMPA use. Our experience indicates that DMPA as a contraceptive is effective and should be available for suitable clients who demonstrate oestrogen intolerance.
在11年期间（1976 - 1986年），对810名接受醋酸甲羟孕酮（DMPA）避孕的患者进行了研究。观察到的重要副作用包括闭经（36.3%）、体重增加（15.8%）、体重减轻（10.6%）、子宫出血（6.7%）和月经过多（6.0%）。闭经、月经过多和子宫出血是11%的使用者停用DMPA的主要原因。使用DMPA期间未出现妊娠、生殖器或乳腺恶性肿瘤病例。我们的经验表明，DMPA作为一种避孕药是有效的，对于表现出雌激素不耐受的合适患者应可使用。
