Fraser I S, Dennerstein G J
Department of Obstetrics and Gynaecology, University of Sydney, NSW.
Med J Aust. 1994 May 2;160(9):553-6.
To review the characteristics and experience of Australian women treated with depot medroxyprogesterone acetate (DMPA) in one gynaecological practice in Melbourne since 1973.
A detailed retrospective review of clinical data on 363 women treated with a total of 2298 injections of DMPA over the past 20 years.
The main indication was contraception, although a substantial minority (20%) were treated with DMPA predominantly for medical indications such as endometriosis. No pregnancy occurred within three months of an injection. There was also high acceptability, with a mean of 6.3 injections per subject, and a mean overall follow-up of 43.3 months. The median delay in the return of fertility in those wishing to conceive immediately was 9.2 months. Only one patient complained of difficulty in conceiving. Menstrual bleeding disturbances only led to 7.3% of the discontinuations, although fairly frequent use of short courses of oral oestrogen (in 40% of women) was employed in the early months of DMPA treatment. Other side effects were relatively infrequent, the most common being superficial dyspareunia or reduced libido (in 8%).
This much maligned drug merits a legitimate place among the contraceptive choices available for Australian women. Accurate, unbiased information about the extensive worldwide experience needs to be made available to all Australian medical practitioners.
回顾自1973年以来在墨尔本一家妇科诊所接受醋酸甲羟孕酮长效注射剂（DMPA）治疗的澳大利亚女性的特征及治疗经验。
对过去20年中363名接受总计2298次DMPA注射治疗的女性的临床数据进行详细的回顾性分析。
主要适应症为避孕，尽管有相当一部分少数患者（20%）主要因子宫内膜异位症等医学适应症而接受DMPA治疗。注射后三个月内未发生妊娠。DMPA的接受度也很高，每位受试者平均注射6.3次，平均总随访时间为43.3个月。希望立即受孕的女性恢复生育能力的中位延迟时间为9.2个月。只有一名患者抱怨受孕困难。月经出血紊乱仅导致7.3%的患者停药，不过在DMPA治疗的最初几个月，相当频繁地使用了短期口服雌激素（40%的女性）。其他副作用相对较少见，最常见的是浅表性交困难或性欲减退（8%）。
这种备受诋毁的药物在澳大利亚女性可选用的避孕方法中理应占有一席之地。需要向所有澳大利亚医生提供有关全球广泛经验的准确、无偏见的信息。
