一种作为手性固定相用于1,1'-联萘-2-萘酚外消旋体手性拆分的表面分子印迹聚合物。

A surface molecularly imprinted polymer as chiral stationary phase for chiral separation of 1,1'-binaphthalene-2-naphthol racemates.

作者信息

Dong Hongxing, Zhang Danxia, Lin Hailong, Wang Yudan, Liu Lijia, Zheng Meixia, Li Xiaobo, Zhang Chunhong, Li Junqing, Zhang Peng, So Juhyok

机构信息

Institute of Advanced Marine Materials, Key Laboratory of Superlight Materials & Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin, China.

COFCO Nutrition & Health Research Institute, Beijing, China.

出版信息

Chirality. 2017 Jul;29(7):340-347. doi: 10.1002/chir.22710. Epub 2017 May 25.

DOI:10.1002/chir.22710

PMID:28543776

Abstract

Acrylamide (AM) was copolymerized with ethylene glycol dimethacrylate (EGDMA) in the presence of (R)-1,1'-binaphthalene-2-naphthol (BINOL) as the template molecules on the surface of silica gel by a free radical polymerization to produce a chiral stationary phase based on the surface molecularly imprinted polymer (SMIP-CSP). The SMIP-CSP showed a much better separation factor (α = 4.28) than the CSP based on the molecularly imprinted polymer (MIP-CSP) without coating on the silica gel (α = 1.96) during the chiral separation of BINOL enantiomers by high-performance liquid chromatography. The influence of the pretreatment temperature and the content of the template molecule ((R)-BINOL) of the SMIP-CSP, and the mobile phase composition on the separation of the racemic BINOL were systematically investigated.

摘要

在硅胶表面，以（R）-1,1'-联萘-2-萘酚（BINOL）为模板分子，通过自由基聚合使丙烯酰胺（AM）与乙二醇二甲基丙烯酸酯（EGDMA）共聚，制备基于表面分子印迹聚合物（SMIP-CSP）的手性固定相。在高效液相色谱法对手性BINOL对映体进行手性分离过程中，SMIP-CSP表现出比未涂覆在硅胶上的基于分子印迹聚合物的固定相（MIP-CSP）更好的分离因子（α = 4.28）（α = 1.96）。系统研究了SMIP-CSP的预处理温度、模板分子（（R）-BINOL）含量以及流动相组成对外消旋BINOL分离的影响。