反复种植失败女性患者中 CD57 细胞与 CD56 细胞的比值异常。
Abnormal ratio of CD57 cells to CD56 cells in women with recurrent implantation failure.
机构信息
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Central Research Lab, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
出版信息
Am J Reprod Immunol. 2017 Nov;78(5). doi: 10.1111/aji.12708. Epub 2017 May 20.
PROBLEM
To define a more precise parameter for a better understanding of natural killer (NK) cells and its relation with regulatory T cells (Tregs) in women with recurrent implantation failure (RIF).
METHOD OF STUDY
The percentages of CD56+ cells, CD57+ cells and Foxp3+ cells in the endometrium and blood from 23 normal controls and 32 women with RIF were measured by immunocytochemistry and flow cytometry.
RESULTS
Women with RIF had significantly increased ratio of CD57+ cells to CD56+ cells in both the endometrium (P<.01) and blood (P<.05), and decreased percentage of Foxp3+ cells in the endometrium (P<.05). There was a significant negative correlation between CD57+ cells to CD56+ cells ratio and the percentage of Foxp3+ cells in the blood of RIF patients (P<.05).
CONCLUSION
Our study provides a novel assessment parameter, CD57+ cells to CD56+ cells ratio, to evaluate NK cells and its relation with Tregs in RIF patients.
问题
为了更好地理解自然杀伤 (NK) 细胞及其与复发性植入失败 (RIF) 女性中调节性 T 细胞 (Treg) 的关系，定义一个更精确的参数。
研究方法
通过免疫细胞化学和流式细胞术测量了 23 名正常对照组和 32 名 RIF 女性的子宫内膜和血液中 CD56+ 细胞、CD57+ 细胞和 Foxp3+ 细胞的百分比。
结果
RIF 女性的子宫内膜（P<.01）和血液（P<.05）中 CD57+ 细胞与 CD56+ 细胞的比例明显升高，子宫内膜中 Foxp3+ 细胞的百分比降低（P<.05）。RIF 患者血液中 CD57+ 细胞与 CD56+ 细胞的比例与 Foxp3+ 细胞的百分比呈显著负相关（P<.05）。
结论
本研究提供了一个新的评估参数，即 CD57+ 细胞与 CD56+ 细胞的比例，用于评估 RIF 患者的 NK 细胞及其与 Treg 的关系。
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