Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8254-8257. doi: 10.1002/anie.201704492. Epub 2017 Jun 13.
The first total synthesis of waihoensene, a tetracyclic diterpene containing an angular triquinane and a six-membered ring, with four contiguous quaternary carbon atoms, was achieved through the tandem cycloaddition reaction of an allenyl diazo substrate containing a six-membered ring via trimethylenemethane (TMM) diyl intermediate.
通过三环[3.3.0.0 3,7]辛烷二亚基（TMM）中间体中环丙烯基重氮底物的串联环加成反应，实现了含有一个角三尖烷和一个六元环、四个连续季碳原子的四环二萜 waihoensene 的首次全合成。
