（±）-Waihoensene 的全合成。
Total Synthesis of (±)-Waihoensene.
机构信息
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
出版信息
Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8254-8257. doi: 10.1002/anie.201704492. Epub 2017 Jun 13.
PMID:28544050
Abstract
The first total synthesis of waihoensene, a tetracyclic diterpene containing an angular triquinane and a six-membered ring, with four contiguous quaternary carbon atoms, was achieved through the tandem cycloaddition reaction of an allenyl diazo substrate containing a six-membered ring via trimethylenemethane (TMM) diyl intermediate.
摘要
通过三环[3.3.0.0 3,7]辛烷二亚基（TMM）中间体中环丙烯基重氮底物的串联环加成反应，实现了含有一个角三尖烷和一个六元环、四个连续季碳原子的四环二萜 waihoensene 的首次全合成。
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