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CXCL10和IL-6：早产时两种不同形式羊膜内炎症的标志物。

CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor.

作者信息

Romero Roberto, Chaemsaithong Piya, Chaiyasit Noppadol, Docheva Nikolina, Dong Zhong, Kim Chong Jai, Kim Yeon Mee, Kim Jung-Sun, Qureshi Faisal, Jacques Suzanne M, Yoon Bo Hyun, Chaiworapongsa Tinnakorn, Yeo Lami, Hassan Sonia S, Erez Offer, Korzeniewski Steven J

机构信息

Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

出版信息

Am J Reprod Immunol. 2017 Jul;78(1). doi: 10.1111/aji.12685. Epub 2017 May 19.

DOI:10.1111/aji.12685
PMID:28544362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5488235/
Abstract

PROBLEM

To determine whether amniotic fluid (AF) CXCL10 concentration is associated with histologic chronic chorioamnionitis in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PROM).

METHOD OF STUDY

This study included 168 women who had an episode of PTL or preterm PROM. AF interleukin (IL)-6 and CXCL10 concentrations were determined by immunoassay.

RESULTS

(i) Increased AF CXCL10 concentration was associated with chronic (OR: 4.8; 95% CI: 1.7-14), but not acute chorioamnionitis; (ii) increased AF IL-6 concentration was associated with acute (OR: 4.2; 95% CI: 1.3-13.7) but not chronic chorioamnionitis; and (iii) an increase in AF CXCL10 concentration was associated with placental lesions consistent with maternal anti-fetal rejection (OR: 3.7; 95% CI: 1.3-10.4). (iv) All patients with elevated AF CXCL10 and IL-6 delivered preterm.

CONCLUSION

Increased AF CXCL10 concentration is associated with chronic chorioamnionitis or maternal anti-fetal rejection, whereas increased AF IL-6 concentration is associated with acute histologic chorioamnionitis.

摘要

问题

确定羊水（AF）CXCL10浓度是否与早产（PTL）和胎膜早破（PROM）患者的组织学慢性绒毛膜羊膜炎相关。

研究方法

本研究纳入了168例发生PTL或早产PROM的女性。通过免疫测定法测定羊水白细胞介素（IL）-6和CXCL10浓度。

结果

（i）羊水CXCL10浓度升高与慢性绒毛膜羊膜炎相关（比值比：4.8；95%置信区间：1.7 - 14），但与急性绒毛膜羊膜炎无关；（ii）羊水IL-6浓度升高与急性绒毛膜羊膜炎相关（比值比：4.2；95%置信区间：1.3 - 13.7），但与慢性绒毛膜羊膜炎无关；（iii）羊水CXCL10浓度升高与符合母体抗胎儿排斥的胎盘病变相关（比值比：3.7；95%置信区间：1.3 - 10.4）。（iv）所有羊水CXCL10和IL-6升高的患者均早产。

结论

羊水CXCL10浓度升高与慢性绒毛膜羊膜炎或母体抗胎儿排斥相关，而羊水IL-6浓度升高与急性组织学绒毛膜羊膜炎相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fee/5488235/2c1266da3c3f/AJI-78-na-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fee/5488235/2f44613ac861/AJI-78-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fee/5488235/0de6209cba46/AJI-78-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fee/5488235/fe104aa84a43/AJI-78-na-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fee/5488235/2c1266da3c3f/AJI-78-na-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fee/5488235/2f44613ac861/AJI-78-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fee/5488235/0de6209cba46/AJI-78-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fee/5488235/fe104aa84a43/AJI-78-na-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fee/5488235/2c1266da3c3f/AJI-78-na-g004.jpg

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