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In vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth.单克隆αCD3ε抗体在体内激活T细胞会引发早产和分娩。
Am J Reprod Immunol. 2016 Nov;76(5):386-390. doi: 10.1111/aji.12562. Epub 2016 Sep 23.
3
Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone.不变自然杀伤T细胞激活诱导晚期早产，而罗格列酮可减轻这种情况。
J Immunol. 2016 Feb 1;196(3):1044-59. doi: 10.4049/jimmunol.1501962. Epub 2016 Jan 6.
4
Chemokine Receptor Expression on Normal Blood CD56(+) NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population.趋化因子受体在正常血 CD56(+)NK 细胞上的表达阐明了固有和适应性免疫反应中共同迁移的细胞伙伴，并鉴定了一个过渡性 NK 细胞群体。
J Immunol Res. 2015;2015:839684. doi: 10.1155/2015/839684. Epub 2015 Oct 12.
5
Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance.胎盘的慢性炎症：定义、分类、发病机制及临床意义。
Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S53-69. doi: 10.1016/j.ajog.2015.08.041.
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Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance.急性绒毛膜羊膜炎和脐带炎：定义、病理特征及临床意义。
Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S29-52. doi: 10.1016/j.ajog.2015.08.040.
7
Classification of placental lesions.胎盘病变的分类。
Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S21-8. doi: 10.1016/j.ajog.2015.05.056.
8
Risk factors for preterm birth and new approaches to its early diagnosis.早产的风险因素及其早期诊断的新方法。
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9
Does progesterone administration in preterm labor influence Treg cells?早产时使用孕酮会影响调节性T细胞吗？
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Chemokines and transplant outcome.趋化因子与移植结果。
Clin Biochem. 2016 Mar;49(4-5):355-62. doi: 10.1016/j.clinbiochem.2015.07.026. Epub 2015 Aug 1.

胎盘慢性炎症性病变与羊水CXCR3上调有关：同种异体移植排斥反应的一个标志物。

Chronic inflammatory lesions of the placenta are associated with an up-regulation of amniotic fluid CXCR3: A marker of allograft rejection.

作者信息

Maymon Eli, Romero Roberto, Bhatti Gaurav, Chaemsaithong Piya, Gomez-Lopez Nardhy, Panaitescu Bogdan, Chaiyasit Noppadol, Pacora Percy, Dong Zhong, Hassan Sonia S, Erez Offer

机构信息

Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI, USA.

出版信息

J Perinat Med. 2018 Feb 23;46(2):123-137. doi: 10.1515/jpm-2017-0042.

DOI:10.1515/jpm-2017-0042
PMID:28829757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5797487/
Abstract

OBJECTIVE

The objective of this study is to determine whether the amniotic fluid (AF) concentration of soluble CXCR3 and its ligands CXCL9 and CXCL10 changes in patients whose placentas show evidence of chronic chorioamnionitis or other placental lesions consistent with maternal anti-fetal rejection.

METHODS

This retrospective case-control study included 425 women with (1) preterm delivery (n=92); (2) term in labor (n=68); and (3) term not in labor (n=265). Amniotic fluid CXCR3, CXCL9 and CXCL10 concentrations were determined by ELISA.

RESULTS

(1) Amniotic fluid concentrations of CXCR3 and its ligands CXCL9 and CXCL10 are higher in patients with preterm labor and maternal anti-fetal rejection lesions than in those without these lesions [CXCR3: preterm labor and delivery with maternal anti-fetal rejection placental lesions (median, 17.24 ng/mL; IQR, 6.79-26.68) vs. preterm labor and delivery without these placental lesions (median 8.79 ng/mL; IQR, 4.98-14.7; P=0.028)]; (2) patients with preterm labor and chronic chorioamnionitis had higher AF concentrations of CXCL9 and CXCL10, but not CXCR3, than those without this lesion [CXCR3: preterm labor with chronic chorioamnionitis (median, 17.02 ng/mL; IQR, 5.57-26.68) vs. preterm labor without chronic chorioamnionitis (median, 10.37 ng/mL; IQR 5.01-17.81; P=0.283)]; (3) patients with preterm labor had a significantly higher AF concentration of CXCR3 than those in labor at term regardless of the presence or absence of placental lesions.

CONCLUSION

Our findings support a role for maternal anti-fetal rejection in a subset of patients with preterm labor.

摘要

目的

本研究旨在确定胎盘显示慢性绒毛膜羊膜炎证据或其他与母体抗胎儿排斥相符的胎盘病变的患者，其羊水（AF）中可溶性CXCR3及其配体CXCL9和CXCL10的浓度是否发生变化。

方法

这项回顾性病例对照研究纳入了425名女性，她们分别为：（1）早产（n = 92）；（2）足月临产（n = 68）；（3）足月未临产（n = 265）。采用酶联免疫吸附测定法（ELISA）测定羊水CXCR3、CXCL9和CXCL10的浓度。

结果

（1）早产且有母体抗胎儿排斥病变的患者，其羊水CXCR3及其配体CXCL9和CXCL10的浓度高于无这些病变的患者[CXCR3：早产且有母体抗胎儿排斥胎盘病变（中位数，17.24 ng/mL；四分位间距，6.79 - 26.68） vs. 早产且无这些胎盘病变（中位数8.79 ng/mL；四分位间距，4.98 - 14.7；P = 0.028）]；（2）早产且有慢性绒毛膜羊膜炎的患者，其羊水CXCL9和CXCL10的浓度高于无此病变的患者，但CXCR3浓度无差异[CXCR3：早产且有慢性绒毛膜羊膜炎（中位数，17.02 ng/mL；四分位间距，5.57 - 26.68） vs. 早产且无慢性绒毛膜羊膜炎（中位数，10.37 ng/mL；四分位间距5.01 - 17.81；P = 0.283）]；（3）无论有无胎盘病变，早产患者羊水CXCR3的浓度均显著高于足月临产患者。

结论

我们的研究结果支持母体抗胎儿排斥在一部分早产患者中起作用。