Department of Chemistry, Birla Institute of Technology and Sciences, Pilani, 333031, India.
Chem Asian J. 2017 Aug 4;12(15):1869-1874. doi: 10.1002/asia.201700538. Epub 2017 Jun 26.
An efficient approach towards peptide synthesis that allows easy access to variety of small peptides via one-pot aziridine-mediated ligation/desulfurization strategy has been described. The protocol afforded a library of phenylalanine- and tryptophan-containing α-peptides in good yields by regioselective ring-opening of aziridine-3-aryl-2-carboxylates with peptide thioacids, followed by desulfurization.
已经描述了一种有效的肽合成方法，该方法通过一锅法氮丙啶介导的连接/脱硫策略，可轻松获得各种小肽。该方案通过氮丙啶-3-芳基-2-羧酸酯与肽硫代酸的区域选择性开环，然后脱硫，以良好的收率得到了包含苯丙氨酸和色氨酸的α-肽的文库。
