Ahmed Saeed, Sabelli Rachael A, Simon Katie, Rosenberg Nora E, Kavuta Elijah, Harawa Mwelura, Dick Spencer, Linzie Frank, Kazembe Peter N, Kim Maria H
Abbott Fund Children's Clinical Center of Excellence, Baylor College of Medicine, Lilongwe, Malawi.
Baylor International Pediatric AIDS Initiative at Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Trop Med Int Health. 2017 Aug;22(8):1021-1029. doi: 10.1111/tmi.12900. Epub 2017 Jun 20.
Evaluation of a novel index case finding and linkage-to-care programme to identify and link HIV-infected children (1-15 years) and young persons (>15-24 years) to care.
HIV-infected patients enrolled in HIV services were screened and those who reported untested household members (index cases) were offered home- or facility-based HIV testing and counselling (HTC) of their household by a community health worker (CHW). HIV-infected household members identified were enrolled in a follow-up programme offering home and facility-based follow-up by CHWs.
Of the 1567 patients enrolled in HIV services, 1030 (65.7%) were screened and 461 (44.8%) identified as index cases; 93.5% consented to HIV testing of their households and of those, 279 (64.7%) reported an untested child or young person. CHWs tested 711 children and young persons, newly diagnosed 28 HIV-infected persons (yield 4.0%; 95% CI: 2.7-5.6), and identified an additional two HIV-infected persons not enrolled in care. Of the 30 HIV-infected persons identified, 23 (76.6%) were linked to HIV services; 18 of the 20 eligible for ART (90.0%) were initiated. Median time (IQR) from identification to enrolment into HIV services was 4 days (1-8) and from identification to ART start was 6 days (1-8).
Almost half of HIV-infected patients enrolled in treatment services had untested household members, many of whom were children and young persons. Index case finding, coupled with home-based testing and tracked follow-up, is acceptable, feasible and facilitates the identification and timely linkage to care of HIV-infected children and young persons.
评估一项新型的索引病例发现及护理联系项目,以识别感染艾滋病毒的儿童(1至15岁)和年轻人(大于15至24岁)并为其提供护理。
对参加艾滋病毒服务的艾滋病毒感染患者进行筛查,那些报告有未检测家庭成员(索引病例)的患者,由社区卫生工作者为其家庭提供基于家庭或机构的艾滋病毒检测和咨询(HTC)。确定感染艾滋病毒的家庭成员被纳入一项随访项目,由社区卫生工作者提供基于家庭和机构的随访。
在参加艾滋病毒服务的1567名患者中,1030名(65.7%)接受了筛查,461名(44.8%)被确定为索引病例;93.5%的人同意对其家庭进行艾滋病毒检测,其中279名(64.7%)报告有未检测的儿童或年轻人。社区卫生工作者对711名儿童和年轻人进行了检测,新诊断出28名艾滋病毒感染者(检出率4.0%;95%置信区间:2.7 - 5.6),并另外确定了2名未参加护理的艾滋病毒感染者。在确定的30名艾滋病毒感染者中,23名(76.6%)与艾滋病毒服务建立了联系;20名符合抗逆转录病毒治疗条件的患者中有18名(90.0%)开始接受治疗。从确定到纳入艾滋病毒服务的中位时间(四分位间距)为4天(1 - 8天),从确定到开始抗逆转录病毒治疗的中位时间为6天(1 - 8天)。
参加治疗服务的艾滋病毒感染患者中,近一半有未检测的家庭成员,其中许多是儿童和年轻人。索引病例发现,加上基于家庭的检测和跟踪随访,是可接受的、可行的,并有助于识别感染艾滋病毒的儿童和年轻人并及时为其提供护理。