Ozaki Satoru, Kasashima Satomi, Kawashima Atsuhiro, Ooi Akishi
Department of Clinical Laboratory Science, Kanazawa University, Kanazawa, Japan.
Department of Pathology, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan.
Diagn Cytopathol. 2018 Sep;46(9):739-743. doi: 10.1002/dc.23762. Epub 2017 May 24.
Myxoinflammatory fibroblastic sarcoma (MIFS) is rare low-grade soft-tissue tumor that occurs in extremities. Clinically it is difficult to differentiate from benign lesions, such as nodular fasciitis, and malignant tumors, such as liposarcoma. We report a case of MIFS in the forearm of a 34-year-old man. The resected tumor measured 5.3 × 2.7 × 2.5 cm , had a lobular structure with indistinct boundary, and consisted of a large amount of translucent and yellow mucous-like substrate. Cytological examination of a preoperative puncture aspiration specimen showed histiocyte- and fibroblast-like tumor cells in a mucous-like matrix together with scattered lipoblast- and ganglion-like cells. Nuclear chromatin of the tumor cells showed a fine granular appearance but no notable hyperchromasia. There were no clear malignant findings. On Giemsa staining of the tumor cells, there were fine granular and hyaline intracytoplasmic substances that showed purple to reddish-purple metachromaticity. Prominent inflammatory cells were not observed in the specimens. MIFS should be considered in the differential diagnosis for a myxoid tumor in the extremities.
黏液炎性纤维母细胞肉瘤（MIFS）是一种罕见的发生于四肢的低度恶性软组织肿瘤。临床上，它很难与良性病变（如结节性筋膜炎）以及恶性肿瘤（如脂肪肉瘤）相鉴别。我们报告一例34岁男性前臂的MIFS病例。切除的肿瘤大小为5.3×2.7×2.5厘米，呈分叶状结构，边界不清，由大量半透明的黄色黏液样基质组成。术前穿刺抽吸标本的细胞学检查显示，在黏液样基质中有组织细胞样和成纤维细胞样肿瘤细胞，以及散在的脂肪母细胞样和神经节样细胞。肿瘤细胞核染色质呈细颗粒状，但无明显的深染。未见明确的恶性表现。对肿瘤细胞进行吉姆萨染色，可见细颗粒状和透明的胞质内物质，呈紫色至红紫色异染性。标本中未观察到显著的炎症细胞。对于四肢的黏液样肿瘤，鉴别诊断时应考虑MIFS。
