Wickham M Quinn, Youens Kenneth E, Dodd Leslie G
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Diagn Cytopathol. 2012 Aug;40 Suppl 2:E144-8. doi: 10.1002/dc.21721. Epub 2011 May 4.
Cytological diagnosis of low grade sarcomas can be a daunting task, owing to the varied cytomorphological appearances possible. We report a case of acral myxoinflammatory fibroblastic sarcoma (AMIFS) in a woman who presented with a longstanding mass on the dorsum of her left foot. The diagnosis was suggested by fine needle aspiration cytology and established by wide excision. Microscopic examination showed that fine needle aspirate smears of this lesion contained the characteristic features seen in the surgical excision of this AMIFS: myxoid material, spindled to epithelioid cells with variably prominent nucleoli, nuclear pseudoinclusions, bipolar cytoplasmic extensions, globules of extracellular material, and bizarre virocyte or ganglion-like giant cells.
由于低级别肉瘤可能出现多种细胞形态学表现，其细胞学诊断可能是一项艰巨的任务。我们报告一例发生于一名女性的足部黏液炎性纤维母细胞肉瘤（AMIFS），该患者左脚背有一长期存在的肿块。细针穿刺细胞学检查提示了诊断，并通过广泛切除得以确诊。显微镜检查显示，该病变的细针穿刺涂片包含了在该AMIFS手术切除标本中所见的特征性表现：黏液样物质、梭形至上皮样细胞，核仁大小不一、核内假包涵体、双极胞质突起、细胞外物质小球，以及怪异的病毒样细胞或神经节样巨细胞。
