Wennberg Alexandra M V, Hagen Clinton E, Gottesman Rebecca F, Zipunnikov Vadim, Kaufmann Christopher N, Albert Marilyn S, Rebok George W, Kasper Judith D, Spira Adam P
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States.
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States.
Arch Gerontol Geriatr. 2017 Sep;72:39-44. doi: 10.1016/j.archger.2017.05.005. Epub 2017 May 16.
Type II diabetes mellitus (DM) is associated with increased risk of dementia; however, few studies have examined the longitudinal association between DM and cognitive outcomes in large nationally representative cohorts. We investigated these associations in 7605 participants enrolled in the National Health and Aging Trends Study, a nationally representative prospective study of Medicare beneficiaries ≥65, from 2011 to 2015. Participants or proxy respondents reported DM and dementia diagnosis, and participants completed immediate and delayed recall word list learning tests and the Clock Drawing Test. In multivariable-adjusted generalized linear mixed models, baseline DM diagnosis was associated with decline on immediate and delayed word recall and the Clock Drawing Test. In Cox proportional hazards models, DM also predicted incident dementia in older age groups at baseline. These findings further support the notion that DM is associated with cognitive outcomes, suggesting that treatment and prevention of DM may reduce the risk of these outcomes. However, more studies are needed to better understand whether DM treatments affect this relationship.
2型糖尿病（DM）与痴呆风险增加相关；然而，很少有研究在具有全国代表性的大型队列中考察DM与认知结局之间的纵向关联。我们在参加国家健康与老龄化趋势研究的7605名参与者中调查了这些关联，该研究是一项针对≥65岁医疗保险受益人的具有全国代表性的前瞻性研究，时间跨度为2011年至2015年。参与者或代理受访者报告了DM和痴呆诊断情况，参与者完成了即时和延迟回忆单词列表学习测试以及画钟测试。在多变量调整的广义线性混合模型中，基线DM诊断与即时和延迟单词回忆以及画钟测试的下降有关。在Cox比例风险模型中，DM在基线时也预测了老年组的痴呆发病情况。这些发现进一步支持了DM与认知结局相关的观点，表明DM的治疗和预防可能会降低这些结局的风险。然而，需要更多的研究来更好地理解DM治疗是否会影响这种关系。
