Zhang Zhe, Wang Busen, Wu Shipo, Wen Yanbo, Wang Xinyi, Song Xiaohong, Zhang Jinlong, Hou Lihua, Chen Wei
Beijing Institute of Biotechnology, Beijing 100071, China.
Beijing Institute of Biotechnology, Beijing 100071, China.
Virology. 2017 Aug;508:150-158. doi: 10.1016/j.virol.2017.05.012. Epub 2017 May 22.
Enterovirus71 (EV71) is the major causative agent of hand, foot and mouth disease, which threatens the health of infants and young children. The expression of inflammatory cytokines induced by this viral infection aggravate the illness. Here, we describe the anti-EV71 activity of a specific p38 inhibitor that regulates the p38-MAPK signaling pathway. PD169316 was specifically selected from a MAPK compound library due to its significant inhibitory effect on EV71 replication. PD169316 also reduced EV71-induced apoptosis. Animal experiments showed that PD169316 can dampen the replication of EV71, reduce tissue damage and inhibit the release of inflammatory cytokines, thereby alleviating the severe diseases caused by EV71 in suckling mice.
肠道病毒71型（EV71）是手足口病的主要病原体，威胁着婴幼儿的健康。这种病毒感染诱导的炎性细胞因子表达会加重病情。在此，我们描述了一种调节p38丝裂原活化蛋白激酶（MAPK）信号通路的特异性p38抑制剂的抗EV71活性。PD169316因其对EV71复制具有显著抑制作用而从MAPK化合物库中被特意挑选出来。PD169316还减少了EV71诱导的细胞凋亡。动物实验表明，PD169316可抑制EV71的复制，减轻组织损伤并抑制炎性细胞因子的释放，从而缓解乳鼠中由EV71引起的严重疾病。
